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000292357 1001_ $$0P:(DE-He78)4cbe3abf3c7df5d7fbac1c945e4c2fce$$aLi, Zhe$$b0$$eFirst author
000292357 245__ $$aAffinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination.
000292357 260__ $$aNew York, NY$$bElsevier$$c2024
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000292357 500__ $$a#EA:D130#LA:D130# / 2024 Sep 10;57(9):2191-2201.e5
000292357 520__ $$aMemory B cells (MBCs) formed over the individual's lifetime constitute nearly half of the circulating B cell repertoire in humans. These pre-existing MBCs dominate recall responses to their cognate antigens, but how they respond to recognition of novel antigens is not well understood. Here, we tracked the origin and followed the differentiation paths of MBCs in the early anti-spike (S) response to mRNA vaccination in SARS-CoV-2-naive individuals on single-cell and monoclonal antibody levels. Pre-existing, highly mutated MBCs showed no signs of germinal center re-entry and rapidly developed into mature antibody-secreting cells (ASCs). By contrast, and despite similar levels of S reactivity, naive B cells showed strong signs of antibody affinity maturation before differentiating into MBCs and ASCs. Thus, pre-existing human MBCs differentiate into ASCs in response to novel antigens, but the quality of the humoral and cellular anti-S response improved through the clonal selection and affinity maturation of naive precursors.
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000292357 650_7 $$2Other$$aSARS-CoV-2
000292357 650_7 $$2Other$$aaffinity maturation
000292357 650_7 $$2Other$$agerminal center
000292357 650_7 $$2Other$$ahumoral immunity
000292357 650_7 $$2Other$$amRNA vaccination
000292357 650_7 $$2Other$$apre-existing memory B cells
000292357 650_7 $$2Other$$asomatic hypermutation
000292357 7001_ $$0P:(DE-He78)e74839b6d00040170cd36ad1b243979d$$aObraztsova, Anna$$b1$$eFirst author
000292357 7001_ $$0P:(DE-He78)8379c86250c50c0537999a6576e18aa7$$aShang, Fuwei$$b2
000292357 7001_ $$0P:(DE-He78)0553af257ddaca21e5e06ea6780b2895$$aOludada, Opeyemi$$b3
000292357 7001_ $$0P:(DE-He78)e469468b5d6134e74ede38a064bc0ecc$$aMalapit, Joshua$$b4
000292357 7001_ $$0P:(DE-He78)6695811f3270b3dbe3d06842e2ca55cd$$aBusch, Katrin$$b5
000292357 7001_ $$0P:(DE-He78)604bb0ebdb4e4aa550668663597c9ec8$$avan Straaten, Monique$$b6
000292357 7001_ $$0P:(DE-He78)3e1497ece09f8d2c69efc8b106a08f2b$$aStebbins, Erec$$b7
000292357 7001_ $$0P:(DE-He78)054f6f018d61d9e639fe25324954e8df$$aMurugan, Rajagopal$$b8
000292357 7001_ $$0P:(DE-He78)03b354519d912a2724af6b7c9106d1f5$$aWardemann, Hedda$$b9$$eLast author
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