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@ARTICLE{Li:292357,
      author       = {Z. Li$^*$ and A. Obraztsova$^*$ and F. Shang$^*$ and O.
                      Oludada$^*$ and J. Malapit$^*$ and K. Busch$^*$ and M. van
                      Straaten$^*$ and E. Stebbins$^*$ and R. Murugan$^*$ and H.
                      Wardemann$^*$},
      title        = {{A}ffinity-independent memory {B} cell origin of the early
                      antibody-secreting cell response in naive individuals upon
                      {SARS}-{C}o{V}-2 vaccination.},
      journal      = {Immunity},
      volume       = {57},
      number       = {9},
      issn         = {1074-7613},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01706},
      pages        = {2191-2201.e5},
      year         = {2024},
      note         = {#EA:D130#LA:D130# / 2024 Sep 10;57(9):2191-2201.e5},
      abstract     = {Memory B cells (MBCs) formed over the individual's lifetime
                      constitute nearly half of the circulating B cell repertoire
                      in humans. These pre-existing MBCs dominate recall responses
                      to their cognate antigens, but how they respond to
                      recognition of novel antigens is not well understood. Here,
                      we tracked the origin and followed the differentiation paths
                      of MBCs in the early anti-spike (S) response to mRNA
                      vaccination in SARS-CoV-2-naive individuals on single-cell
                      and monoclonal antibody levels. Pre-existing, highly mutated
                      MBCs showed no signs of germinal center re-entry and rapidly
                      developed into mature antibody-secreting cells (ASCs). By
                      contrast, and despite similar levels of S reactivity, naive
                      B cells showed strong signs of antibody affinity maturation
                      before differentiating into MBCs and ASCs. Thus,
                      pre-existing human MBCs differentiate into ASCs in response
                      to novel antigens, but the quality of the humoral and
                      cellular anti-S response improved through the clonal
                      selection and affinity maturation of naive precursors.},
      keywords     = {SARS-CoV-2 (Other) / affinity maturation (Other) / germinal
                      center (Other) / humoral immunity (Other) / mRNA vaccination
                      (Other) / pre-existing memory B cells (Other) / somatic
                      hypermutation (Other)},
      cin          = {D110 / D160 / D130},
      ddc          = {610},
      cid          = {I:(DE-He78)D110-20160331 / I:(DE-He78)D160-20160331 /
                      I:(DE-He78)D130-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39168129},
      doi          = {10.1016/j.immuni.2024.07.023},
      url          = {https://inrepo02.dkfz.de/record/292357},
}