% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Parasyraki:292526,
      author       = {E. Parasyraki and M. Mallick and V. Hatch and V. Vastolo
                      and M. U. Musheev and E. Karaulanov and A. Gopanenko and S.
                      Moxon and M. Méndez-Lago and D. Han and L. Schomacher and
                      D. Mukherjee and C. Niehrs$^*$},
      title        = {5-{F}ormylcytosine is an activating epigenetic mark for
                      {RNA} {P}ol {III} during zygotic reprogramming.},
      journal      = {Cell},
      volume       = {187},
      number       = {21},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01772},
      pages        = {6088-6103.e18},
      year         = {2024},
      note         = {#LA:A050# / 2024 Oct 17;187(21):6088-6103.e18 / DKFZ-ZMBH
                      Alliance},
      abstract     = {5-Methylcytosine (5mC) is an established epigenetic mark in
                      vertebrate genomic DNA, but whether its oxidation
                      intermediates formed during TET-mediated DNA demethylation
                      possess an instructive role of their own that is also
                      physiologically relevant remains unresolved. Here, we reveal
                      a 5-formylcytosine (5fC) nuclear chromocenter, which
                      transiently forms during zygotic genome activation (ZGA) in
                      Xenopus and mouse embryos. We identify this chromocenter as
                      the perinucleolar compartment, a structure associated with
                      RNA Pol III transcription. In Xenopus embryos, 5fC is highly
                      enriched on Pol III target genes activated at ZGA, notably
                      at oocyte-type tandem arrayed tRNA genes. By manipulating
                      Tet and Tdg enzymes, we show that 5fC is required as a
                      regulatory mark to promote Pol III recruitment as well as
                      tRNA expression. Concordantly, 5fC modification of a tRNA
                      transgene enhances its expression in vivo. The results
                      establish 5fC as an activating epigenetic mark during
                      zygotic reprogramming of Pol III gene expression.},
      keywords     = {5-formylcytosine (Other) / B-box (Other) / RNA Pol III
                      (Other) / TDG (Other) / TET (Other) / Xenopus (Other) / ZGA
                      (Other) / perinucleolar compartment (Other) / tRNA (Other) /
                      tRNA-iMet (Other)},
      cin          = {A050},
      ddc          = {610},
      cid          = {I:(DE-He78)A050-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39214079},
      doi          = {10.1016/j.cell.2024.08.011},
      url          = {https://inrepo02.dkfz.de/record/292526},
}