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000292591 1001_ $$0P:(DE-He78)2e92d0ae281932fc7347d819fec36b0b$$aAugustin, Hellmut$$b0$$eLast author$$udkfz
000292591 245__ $$aA systems view of the vascular endothelium in health and disease.
000292591 260__ $$aNew York, NY$$bElsevier$$c2024
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000292591 520__ $$aThe dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endothelium as a whole should be considered a highly dynamic and interactive systemically disseminated organ. We present here a holistic view of the field of vascular research and review the diverse functions of blood-vessel-lining endothelial cells during the life cycle of the vasculature, namely responsive and relaying functions of the vascular endothelium and the responsive roles as instructive gatekeepers of organ function. Emerging translational perspectives in regenerative medicine, preventive medicine, and aging research are developed. Collectively, this review is aimed at promoting disciplinary coherence in the field of angioscience for a broader appreciation of the importance of the vasculature for organ function, systemic health, and healthy aging.
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000292591 650_2 $$2MeSH$$aHumans
000292591 650_2 $$2MeSH$$aEndothelium, Vascular: metabolism
000292591 650_2 $$2MeSH$$aAnimals
000292591 650_2 $$2MeSH$$aEndothelial Cells: metabolism
000292591 650_2 $$2MeSH$$aAging: physiology
000292591 650_2 $$2MeSH$$aRegenerative Medicine
000292591 650_2 $$2MeSH$$aHealth
000292591 7001_ $$aKoh, Gou Young$$b1
000292591 773__ $$0PERI:(DE-600)2001951-8$$a10.1016/j.cell.2024.07.012$$gVol. 187, no. 18, p. 4833 - 4858$$n18$$p4833 - 4858$$tCell$$v187$$x0092-8674$$y2024
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