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| Home > Publications database > A systems view of the vascular endothelium in health and disease. |
| Home > Publications database > A systems view of the vascular endothelium in health and disease. |
| Journal Article (Review Article) | DKFZ-2024-01821 |
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2024
Elsevier
New York, NY
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Please use a persistent id in citations: doi:10.1016/j.cell.2024.07.012
Abstract: The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endothelium as a whole should be considered a highly dynamic and interactive systemically disseminated organ. We present here a holistic view of the field of vascular research and review the diverse functions of blood-vessel-lining endothelial cells during the life cycle of the vasculature, namely responsive and relaying functions of the vascular endothelium and the responsive roles as instructive gatekeepers of organ function. Emerging translational perspectives in regenerative medicine, preventive medicine, and aging research are developed. Collectively, this review is aimed at promoting disciplinary coherence in the field of angioscience for a broader appreciation of the importance of the vasculature for organ function, systemic health, and healthy aging.
Keyword(s): Humans (MeSH) ; Endothelium, Vascular: metabolism (MeSH) ; Animals (MeSH) ; Endothelial Cells: metabolism (MeSH) ; Aging: physiology (MeSH) ; Regenerative Medicine (MeSH) ; Health (MeSH)
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