TY  - JOUR
AU  - Augustin, Hellmut
AU  - Koh, Gou Young
TI  - A systems view of the vascular endothelium in health and disease.
JO  - Cell
VL  - 187
IS  - 18
SN  - 0092-8674
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2024-01821
SP  - 4833 - 4858
PY  - 2024
N1  - #LA:A190#
AB  - The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endothelium as a whole should be considered a highly dynamic and interactive systemically disseminated organ. We present here a holistic view of the field of vascular research and review the diverse functions of blood-vessel-lining endothelial cells during the life cycle of the vasculature, namely responsive and relaying functions of the vascular endothelium and the responsive roles as instructive gatekeepers of organ function. Emerging translational perspectives in regenerative medicine, preventive medicine, and aging research are developed. Collectively, this review is aimed at promoting disciplinary coherence in the field of angioscience for a broader appreciation of the importance of the vasculature for organ function, systemic health, and healthy aging.
KW  - Humans
KW  - Endothelium, Vascular: metabolism
KW  - Animals
KW  - Endothelial Cells: metabolism
KW  - Aging: physiology
KW  - Regenerative Medicine
KW  - Health
LB  - PUB:(DE-HGF)16
C6  - pmid:39241746
DO  - DOI:10.1016/j.cell.2024.07.012
UR  - https://inrepo02.dkfz.de/record/292591
ER  -