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@ARTICLE{Augustin:292591,
      author       = {H. Augustin$^*$ and G. Y. Koh},
      title        = {{A} systems view of the vascular endothelium in health and
                      disease.},
      journal      = {Cell},
      volume       = {187},
      number       = {18},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01821},
      pages        = {4833 - 4858},
      year         = {2024},
      note         = {#LA:A190#},
      abstract     = {The dysfunction of blood-vessel-lining endothelial cells is
                      a major cause of mortality. Although endothelial cells,
                      being present in all organs as a single-cell layer, are
                      often conceived as a rather inert cell population, the
                      vascular endothelium as a whole should be considered a
                      highly dynamic and interactive systemically disseminated
                      organ. We present here a holistic view of the field of
                      vascular research and review the diverse functions of
                      blood-vessel-lining endothelial cells during the life cycle
                      of the vasculature, namely responsive and relaying functions
                      of the vascular endothelium and the responsive roles as
                      instructive gatekeepers of organ function. Emerging
                      translational perspectives in regenerative medicine,
                      preventive medicine, and aging research are developed.
                      Collectively, this review is aimed at promoting disciplinary
                      coherence in the field of angioscience for a broader
                      appreciation of the importance of the vasculature for organ
                      function, systemic health, and healthy aging.},
      subtyp        = {Review Article},
      keywords     = {Humans / Endothelium, Vascular: metabolism / Animals /
                      Endothelial Cells: metabolism / Aging: physiology /
                      Regenerative Medicine / Health},
      cin          = {A190},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39241746},
      doi          = {10.1016/j.cell.2024.07.012},
      url          = {https://inrepo02.dkfz.de/record/292591},
}