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000293274 1001_ $$0P:(DE-He78)036b60c419272e509b5b5db5246c13bc$$aGenard, Geraldine$$b0$$eFirst author
000293274 245__ $$aLipid droplets and small extracellular vesicles: More than two independent entities.
000293274 260__ $$aHoboken, New Jersey$$bWiley$$c2024
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000293274 520__ $$aDespite increasing knowledge about small extracellular vesicle (sEV) composition and functions in cell-cell communication, the mechanism behind their biogenesis remains unclear. Here, we reveal for the first time that sEV biogenesis and release into the microenvironment are tightly connected with another important organelle, Lipid Droplets (LDs). The correlation was observed in several human cancer cell lines as well as patient-derived colorectal cancer stem cells (CR-CSCs). Our results demonstrated that external stimuli such as radiation, pH, hypoxia or lipid-interfering drugs, known to affect the number of LDs/cell, similarly influenced sEV secretion. Importantly, through multiple omics data, at both mRNA and protein levels, we revealed RAB5C as a potential important molecular player behind this organelle connection. Altogether, the potential to fine-tune sEV biogenesis by targeting LDs could significantly impact the amount, cargos and properties of these sEVs, opening new clinical perspectives.
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000293274 650_7 $$2Other$$aRab
000293274 650_7 $$2Other$$aexosomes
000293274 650_7 $$2Other$$ahypoxia
000293274 650_7 $$2Other$$airon metabolism
000293274 650_7 $$2Other$$airradiation
000293274 650_7 $$2Other$$alipid droplets
000293274 650_7 $$2Other$$apH
000293274 650_7 $$2Other$$asmall extracellular vesicles
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000293274 7001_ $$0P:(DE-He78)d06e5bb2d0828caa2be79a51825e84e1$$aPagliari, Francesca$$b2$$udkfz
000293274 7001_ $$aDa Silva, Jessica$$b3
000293274 7001_ $$aGiammona, Alessandro$$b4
000293274 7001_ $$aAlquraish, Fatema$$b5
000293274 7001_ $$0P:(DE-HGF)0$$aReyes, Maria Parra$$b6
000293274 7001_ $$0P:(DE-He78)49cc12672fce5c14a91671562fe2456b$$aBordas, Marie$$b7
000293274 7001_ $$0P:(DE-He78)7d52a11d422cd6c34bd3001fe0cd3997$$aMarafioti, Maria Grazia$$b8
000293274 7001_ $$aFranco, Simone Di$$b9
000293274 7001_ $$0P:(DE-HGF)0$$aJanssen, Jeannette$$b10
000293274 7001_ $$0P:(DE-HGF)0$$aGarcia-Calderón, Daniel$$b11
000293274 7001_ $$0P:(DE-He78)15d0e694db442a1762a025b802a56f75$$aHanley, Rachel$$b12
000293274 7001_ $$aNistico, Clelia$$b13
000293274 7001_ $$aFukasawa, Yoshinori$$b14
000293274 7001_ $$0P:(DE-He78)f0c2bd6811990c0fd74ffcd3f59d9712$$aMüller, Torsten$$b15
000293274 7001_ $$0P:(DE-He78)939d5891259c638c1ab053b1456a578c$$aKrijgsveld, Jeroen$$b16$$udkfz
000293274 7001_ $$aTodaro, Matilde$$b17
000293274 7001_ $$aCostanzo, Francesco Saverio$$b18
000293274 7001_ $$aStassi, Giorgio$$b19
000293274 7001_ $$0P:(DE-He78)f2b6a344bfd285e1d62daa3886ffb5fc$$aNessling, Michelle$$b20$$udkfz
000293274 7001_ $$0P:(DE-He78)027fe772631b4a2d7a45c439cdd75ff2$$aRichter, Karsten$$b21$$udkfz
000293274 7001_ $$0P:(DE-He78)5100059e746b377e2e0a37c0e24f6bf7$$aMaass, Kendra K$$b22$$udkfz
000293274 7001_ $$00000-0002-5653-199X$$aLiberale, Carlo$$b23
000293274 7001_ $$0P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aSeco, Joao$$b24$$eLast author$$udkfz
000293274 773__ $$0PERI:(DE-600)3120403-X$$a10.1002/jex2.162$$gVol. 3, no. 9, p. e162$$n9$$pe162$$tJournal of extracellular biology$$v3$$x2768-2811$$y2024
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