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@ARTICLE{Genard:293274,
      author       = {G. Genard$^*$ and L. Tirinato$^*$ and F. Pagliari$^*$ and
                      J. Da Silva and A. Giammona and F. Alquraish and M. P.
                      Reyes$^*$ and M. Bordas$^*$ and M. G. Marafioti$^*$ and S.
                      D. Franco and J. Janssen$^*$ and D. Garcia-Calderón$^*$ and
                      R. Hanley$^*$ and C. Nistico and Y. Fukasawa and T.
                      Müller$^*$ and J. Krijgsveld$^*$ and M. Todaro and F. S.
                      Costanzo and G. Stassi and M. Nessling$^*$ and K.
                      Richter$^*$ and K. K. Maass$^*$ and C. Liberale and J.
                      Seco$^*$},
      title        = {{L}ipid droplets and small extracellular vesicles: {M}ore
                      than two independent entities.},
      journal      = {Journal of extracellular biology},
      volume       = {3},
      number       = {9},
      issn         = {2768-2811},
      address      = {Hoboken, New Jersey},
      publisher    = {Wiley},
      reportid     = {DKFZ-2024-01847},
      pages        = {e162},
      year         = {2024},
      note         = {#EA:E041#LA:E041#},
      abstract     = {Despite increasing knowledge about small extracellular
                      vesicle (sEV) composition and functions in cell-cell
                      communication, the mechanism behind their biogenesis remains
                      unclear. Here, we reveal for the first time that sEV
                      biogenesis and release into the microenvironment are tightly
                      connected with another important organelle, Lipid Droplets
                      (LDs). The correlation was observed in several human cancer
                      cell lines as well as patient-derived colorectal cancer stem
                      cells (CR-CSCs). Our results demonstrated that external
                      stimuli such as radiation, pH, hypoxia or lipid-interfering
                      drugs, known to affect the number of LDs/cell, similarly
                      influenced sEV secretion. Importantly, through multiple
                      omics data, at both mRNA and protein levels, we revealed
                      RAB5C as a potential important molecular player behind this
                      organelle connection. Altogether, the potential to fine-tune
                      sEV biogenesis by targeting LDs could significantly impact
                      the amount, cargos and properties of these sEVs, opening new
                      clinical perspectives.},
      keywords     = {Rab (Other) / exosomes (Other) / hypoxia (Other) / iron
                      metabolism (Other) / irradiation (Other) / lipid droplets
                      (Other) / pH (Other) / small extracellular vesicles (Other)},
      cin          = {E041 / B060 / B230 / W230 / B062},
      ddc          = {570},
      cid          = {I:(DE-He78)E041-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)B230-20160331 / I:(DE-He78)W230-20160331 /
                      I:(DE-He78)B062-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39257626},
      pmc          = {pmc:PMC11386333},
      doi          = {10.1002/jex2.162},
      url          = {https://inrepo02.dkfz.de/record/293274},
}