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| 001 | 293972 | ||
| 005 | 20250815135417.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jid.2024.08.037 |2 doi |
| 024 | 7 | _ | |a pmid:39384018 |2 pmid |
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| 037 | _ | _ | |a DKFZ-2024-02032 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Kuenzel, Natascha Andrea |b 0 |
| 245 | _ | _ | |a Vδ1 T cells integrated in full thickness skin equivalents: a model for the role of human skin-resident γδT cells. |
| 260 | _ | _ | |a Amsterdam |c 2025 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #LA:A110# / Volume 145, Issue 6, June 2025, Pages 1407-1421 / ZZ01 |
| 520 | _ | _ | |a Vδ1 T cells are a subpopulation of γδT cells found in human dermis. In contrast to murine skin-resident γδT cells, much less is known regarding their role and function in skin health and disease. Here we report the successful integration of Vδ1 T cells into long-term fibroblast-derived matrix skin equivalents (SE). We isolated Vδ1 T cells from human blood, where they are rare, and established conditions for the integration and maintenance of the freshly isolated Vδ1 T cells in the SEs. Plated on top of the dermal equivalents (DEs), almost all Vδ1 T cells migrated into the dermal matrix where they exerted their influence on both the DE and the epithelium. Vδ1 T cells contributed to epidermal differentiation as indicated by histology, expression of epidermal differentiation markers and RNAseq expression profile. When complemented with the carcinoma-derived SCC13 cells instead of HaCaT, our data suggest a role for Vδ1 T cells in slowing growth of the tumor cells, as indicated by reduced stratification and changes in gene expression profiles. Together, we demonstrate the successful establishment of human Vδ1 T cell-competent skin and skin carcinoma equivalents (SE, SCE) and provide evidence for molecular and functional consequences of the Vδ1 T cells on their respective environment. |
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| 650 | _ | 7 | |a Vδ1 T cells |2 Other |
| 650 | _ | 7 | |a human immunocompetent skin model |2 Other |
| 650 | _ | 7 | |a immune surveillance |2 Other |
| 650 | _ | 7 | |a squamous cell carcinoma |2 Other |
| 650 | _ | 7 | |a γδT cells |2 Other |
| 700 | 1 | _ | |a Dobner, Jochen |b 1 |
| 700 | 1 | _ | |a Reichert, Doreen |b 2 |
| 700 | 1 | _ | |a Rossi, Andrea |b 3 |
| 700 | 1 | _ | |a Boukamp, Petra |0 P:(DE-He78)c1895aa471c7ac9c7173045464b69b31 |b 4 |e Last author |u dkfz |
| 700 | 1 | _ | |a Esser, Charlotte |b 5 |
| 773 | _ | _ | |a 10.1016/j.jid.2024.08.037 |g p. S0022202X24021730 |0 PERI:(DE-600)2006902-9 |n 6 |p 1407-1421 |t The journal of investigative dermatology |v 145 |y 2025 |x 0022-202X |
| 856 | 4 | _ | |u https://inrepo02.dkfz.de/record/293972/files/1-s2.0-S0022202X24021730-main.pdf |
| 856 | 4 | _ | |u https://inrepo02.dkfz.de/record/293972/files/1-s2.0-S0022202X24021730-main.pdf?subformat=pdfa |x pdfa |
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