%0 Journal Article
%A Panten, Jasper
%A Del Prete, Stefania
%A Cleland, James
%A Saunders, Lauren M
%A van Riet, Job
%A Schneider, Anja
%A Ginno, Paul
%A Schneider, Nina
%A Koch, Marie-Luise
%A Chen, Xuqi
%A Gerstung, Moritz
%A Stegle, Oliver
%A Arnold, Arthur P
%A Turner, James M A
%A Heard, Edith
%A Odom, Duncan
%T Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.
%J Nature Communications
%V 15
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2024-02053
%P 8814
%D 2024
%Z #EA:B270#EA:B260#LA:B270# / 2024 Oct 11;15(1):8814
%X The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
%K Animals
%K Toll-Like Receptor 7: genetics
%K Toll-Like Receptor 7: metabolism
%K Mice, Inbred C57BL
%K X Chromosome: genetics
%K Mice
%K Male
%K Genotype
%K Female
%K Translocation, Genetic
%K Y Chromosome: genetics
%K Gene Dosage
%K Membrane Glycoproteins: genetics
%K Membrane Glycoproteins: metabolism
%K Toll-Like Receptor 7 (NLM Chemicals)
%K Tlr7 protein, mouse (NLM Chemicals)
%K Membrane Glycoproteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39394207
%2 pmc:PMC11470063
%R 10.1038/s41467-024-52640-8
%U https://inrepo02.dkfz.de/record/294013