Journal Article

DKFZ-2024-02053

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.

Panten, J. (First author)DKFZ* ; Del Prete, S. (First author)DKFZ* ; Cleland, J. (First author)DKFZ* ; Saunders, L. M.DKFZ* ; van Riet, J.DKFZ* ; Schneider, A.DKFZ* ; Ginno, P.DKFZ* ; Schneider, N.DKFZ* ; Koch, M.-L.DKFZ* ; Chen, X. ; Gerstung, M.DKFZ* ; Stegle, O.DKFZ* ; Arnold, A. P. ; Turner, J. M. A. ; Heard, E. ; Odom, D. (Last author)DKFZ*

2024
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-024-52640-8

Abstract: The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.

Keyword(s): Animals (MeSH) ; Toll-Like Receptor 7: genetics (MeSH) ; Toll-Like Receptor 7: metabolism (MeSH) ; Mice, Inbred C57BL (MeSH) ; X Chromosome: genetics (MeSH) ; Mice (MeSH) ; Male (MeSH) ; Genotype (MeSH) ; Female (MeSH) ; Translocation, Genetic (MeSH) ; Y Chromosome: genetics (MeSH) ; Gene Dosage (MeSH) ; Membrane Glycoproteins: genetics (MeSH) ; Membrane Glycoproteins: metabolism (MeSH) ; Toll-Like Receptor 7 ; Tlr7 protein, mouse ; Membrane Glycoproteins

Note: #EA:B270#EA:B260#LA:B270# / 2024 Oct 11;15(1):8814

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Contributing Institute(s):

1. B270 Regulatorische Genomik und Evolution von Tumoren (B270)
2. B260 Bioinformatik der Genomik und Systemgenetik (B260)
3. Künstl. Intelligenz in der Onkologie (B450)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2024

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