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000294013 1001_ $$0P:(DE-He78)d4405881b542f40197770d457d737895$$aPanten, Jasper$$b0$$eFirst author$$udkfz
000294013 245__ $$aFour Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.
000294013 260__ $$a[London]$$bNature Publishing Group UK$$c2024
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000294013 520__ $$aThe Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
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000294013 650_7 $$2NLM Chemicals$$aToll-Like Receptor 7
000294013 650_7 $$2NLM Chemicals$$aTlr7 protein, mouse
000294013 650_7 $$2NLM Chemicals$$aMembrane Glycoproteins
000294013 650_2 $$2MeSH$$aAnimals
000294013 650_2 $$2MeSH$$aToll-Like Receptor 7: genetics
000294013 650_2 $$2MeSH$$aToll-Like Receptor 7: metabolism
000294013 650_2 $$2MeSH$$aMice, Inbred C57BL
000294013 650_2 $$2MeSH$$aX Chromosome: genetics
000294013 650_2 $$2MeSH$$aMice
000294013 650_2 $$2MeSH$$aMale
000294013 650_2 $$2MeSH$$aGenotype
000294013 650_2 $$2MeSH$$aFemale
000294013 650_2 $$2MeSH$$aTranslocation, Genetic
000294013 650_2 $$2MeSH$$aY Chromosome: genetics
000294013 650_2 $$2MeSH$$aGene Dosage
000294013 650_2 $$2MeSH$$aMembrane Glycoproteins: genetics
000294013 650_2 $$2MeSH$$aMembrane Glycoproteins: metabolism
000294013 7001_ $$0P:(DE-He78)20426aaa3d8a280bec7febf6e021944c$$aDel Prete, Stefania$$b1$$eFirst author$$udkfz
000294013 7001_ $$0P:(DE-He78)cb40a25468c1870b0c14bff3d300c31d$$aCleland, James$$b2$$eFirst author$$udkfz
000294013 7001_ $$0P:(DE-He78)0ebd8721a159687e0c77fdc075a7fbc9$$aSaunders, Lauren M$$b3$$udkfz
000294013 7001_ $$0P:(DE-He78)6efdda844232d585b4472cecaed85382$$avan Riet, Job$$b4$$udkfz
000294013 7001_ $$0P:(DE-He78)3d9a9410b62194888d8451351f2ed5d2$$aSchneider, Anja$$b5$$udkfz
000294013 7001_ $$0P:(DE-He78)7f014a1941233bf68b64e192fdefc3d0$$aGinno, Paul$$b6$$udkfz
000294013 7001_ $$0P:(DE-He78)1088dd9d9cfbe8e797ae362bcdc691f3$$aSchneider, Nina$$b7$$udkfz
000294013 7001_ $$0P:(DE-He78)6154bf685be3d3443132aea60a61e4c3$$aKoch, Marie-Luise$$b8$$udkfz
000294013 7001_ $$aChen, Xuqi$$b9
000294013 7001_ $$0P:(DE-He78)bf8843f36606c8735a840f6278fa1e90$$aGerstung, Moritz$$b10$$udkfz
000294013 7001_ $$0P:(DE-He78)9aabcfee1a1fc9202398a45a63f0b1e3$$aStegle, Oliver$$b11$$udkfz
000294013 7001_ $$aArnold, Arthur P$$b12
000294013 7001_ $$00000-0003-1722-7677$$aTurner, James M A$$b13
000294013 7001_ $$00000-0001-8052-7117$$aHeard, Edith$$b14
000294013 7001_ $$0P:(DE-He78)4c21317940f3ec566480ebcdcff3e00c$$aOdom, Duncan$$b15$$eLast author$$udkfz
000294013 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-52640-8$$gVol. 15, no. 1, p. 8814$$n1$$p8814$$tNature Communications$$v15$$x2041-1723$$y2024
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