TY  - JOUR
AU  - Panten, Jasper
AU  - Del Prete, Stefania
AU  - Cleland, James
AU  - Saunders, Lauren M
AU  - van Riet, Job
AU  - Schneider, Anja
AU  - Ginno, Paul
AU  - Schneider, Nina
AU  - Koch, Marie-Luise
AU  - Chen, Xuqi
AU  - Gerstung, Moritz
AU  - Stegle, Oliver
AU  - Arnold, Arthur P
AU  - Turner, James M A
AU  - Heard, Edith
AU  - Odom, Duncan
TI  - Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.
JO  - Nature Communications
VL  - 15
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DKFZ-2024-02053
SP  - 8814
PY  - 2024
N1  - #EA:B270#EA:B260#LA:B270# / 2024 Oct 11;15(1):8814
AB  - The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
KW  - Animals
KW  - Toll-Like Receptor 7: genetics
KW  - Toll-Like Receptor 7: metabolism
KW  - Mice, Inbred C57BL
KW  - X Chromosome: genetics
KW  - Mice
KW  - Male
KW  - Genotype
KW  - Female
KW  - Translocation, Genetic
KW  - Y Chromosome: genetics
KW  - Gene Dosage
KW  - Membrane Glycoproteins: genetics
KW  - Membrane Glycoproteins: metabolism
KW  - Toll-Like Receptor 7 (NLM Chemicals)
KW  - Tlr7 protein, mouse (NLM Chemicals)
KW  - Membrane Glycoproteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39394207
C2  - pmc:PMC11470063
DO  - DOI:10.1038/s41467-024-52640-8
UR  - https://inrepo02.dkfz.de/record/294013
ER  -