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@ARTICLE{Panten:294013,
      author       = {J. Panten$^*$ and S. Del Prete$^*$ and J. Cleland$^*$ and
                      L. M. Saunders$^*$ and J. van Riet$^*$ and A. Schneider$^*$
                      and P. Ginno$^*$ and N. Schneider$^*$ and M.-L. Koch$^*$ and
                      X. Chen and M. Gerstung$^*$ and O. Stegle$^*$ and A. P.
                      Arnold and J. M. A. Turner and E. Heard and D. Odom$^*$},
      title        = {{F}our {C}ore {G}enotypes mice harbour a 3.2{MB} {X}-{Y}
                      translocation that perturbs {T}lr7 dosage.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2024-02053},
      pages        = {8814},
      year         = {2024},
      note         = {#EA:B270#EA:B260#LA:B270# / 2024 Oct 11;15(1):8814},
      abstract     = {The Four Core Genotypes (FCG) is a mouse model system used
                      to disentangle the function of sex chromosomes and hormones.
                      We report that a copy of a 3.2 MB region of the X chromosome
                      has translocated to the YSry- chromosome and thus increased
                      the expression of X-linked genes including the
                      single-stranded RNA sensor and autoimmune disease mediator
                      Tlr7. This previously-unreported X-Y translocation
                      complicates the interpretation of studies reliant on
                      C57BL/6J FCG mice.},
      keywords     = {Animals / Toll-Like Receptor 7: genetics / Toll-Like
                      Receptor 7: metabolism / Mice, Inbred C57BL / X Chromosome:
                      genetics / Mice / Male / Genotype / Female / Translocation,
                      Genetic / Y Chromosome: genetics / Gene Dosage / Membrane
                      Glycoproteins: genetics / Membrane Glycoproteins: metabolism
                      / Toll-Like Receptor 7 (NLM Chemicals) / Tlr7 protein, mouse
                      (NLM Chemicals) / Membrane Glycoproteins (NLM Chemicals)},
      cin          = {B270 / B260 / B450},
      ddc          = {500},
      cid          = {I:(DE-He78)B270-20160331 / I:(DE-He78)B260-20160331 /
                      I:(DE-He78)B450-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39394207},
      pmc          = {pmc:PMC11470063},
      doi          = {10.1038/s41467-024-52640-8},
      url          = {https://inrepo02.dkfz.de/record/294013},
}