Home > Publications database > Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage. > print

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005     20250223015303.0
024 7 _ |a 10.1038/s41467-024-52640-8
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100 1 _ |a Panten, Jasper
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245 _ _ |a Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.
260 _ _ |a [London]
|c 2024
|b Nature Publishing Group UK
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500 _ _ |a #EA:B270#EA:B260#LA:B270# / 2024 Oct 11;15(1):8814
520 _ _ |a The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
536 _ _ |a 312 - Funktionelle und strukturelle Genomforschung (POF4-312)
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
650 _ 7 |a Toll-Like Receptor 7
|2 NLM Chemicals
650 _ 7 |a Tlr7 protein, mouse
|2 NLM Chemicals
650 _ 7 |a Membrane Glycoproteins
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Toll-Like Receptor 7: genetics
|2 MeSH
650 _ 2 |a Toll-Like Receptor 7: metabolism
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a X Chromosome: genetics
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Genotype
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Translocation, Genetic
|2 MeSH
650 _ 2 |a Y Chromosome: genetics
|2 MeSH
650 _ 2 |a Gene Dosage
|2 MeSH
650 _ 2 |a Membrane Glycoproteins: genetics
|2 MeSH
650 _ 2 |a Membrane Glycoproteins: metabolism
|2 MeSH
700 1 _ |a Del Prete, Stefania
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700 1 _ |a Cleland, James
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700 1 _ |a Saunders, Lauren M
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700 1 _ |a van Riet, Job
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700 1 _ |a Schneider, Anja
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700 1 _ |a Ginno, Paul
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700 1 _ |a Schneider, Nina
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700 1 _ |a Koch, Marie-Luise
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700 1 _ |a Chen, Xuqi
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700 1 _ |a Gerstung, Moritz
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700 1 _ |a Stegle, Oliver
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700 1 _ |a Arnold, Arthur P
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700 1 _ |a Turner, James M A
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700 1 _ |a Heard, Edith
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700 1 _ |a Odom, Duncan
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773 _ _ |a 10.1038/s41467-024-52640-8
|g Vol. 15, no. 1, p. 8814
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