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@ARTICLE{Weir:294078,
      author       = {K. Weir and N. Vega and V. Busa$^*$ and B. Sajdak and L.
                      Kallestad and D. Merriman and K. Palczewski and J. Carroll
                      and S. Blackshaw},
      title        = {{I}dentification of shared gene expression programs
                      activated in multiple modes of torpor across vertebrate
                      clades.},
      journal      = {Scientific reports},
      volume       = {14},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2024-02099},
      pages        = {24360},
      year         = {2024},
      abstract     = {Torpor encompasses diverse adaptations to extreme
                      environmental stressors such as hibernation, aestivation,
                      brumation, and daily torpor. Here we introduce
                      StrokeofGenus, an analytic pipeline that identifies distinct
                      transcriptomic states and shared gene expression patterns
                      across studies, tissues, and species. We use StrokeofGenus
                      to study multiple and diverse forms of torpor from
                      publicly-available RNA-seq datasets that span eight species
                      and two classes. We identify three transcriptionally
                      distinct states during the cycle of heterothermia:
                      euthermia, torpor, and interbout arousal. We also identify
                      torpor-specific gene expression patterns that are shared
                      both across tissues and between species with over three
                      hundred million years of evolutionary divergence. We further
                      demonstrate the general sharing of gene expression patterns
                      in multiple forms of torpor, implying a common evolutionary
                      origin for this process. Although here we apply
                      StrokeofGenus to analysis of torpor, it can be used to
                      interrogate any other complex physiological processes
                      defined by transient transcriptomic states.},
      keywords     = {Animals / Torpor: genetics / Vertebrates: genetics /
                      Transcriptome / Gene Expression Profiling: methods /
                      Hibernation: genetics / Gene Expression Regulation /
                      Biological Evolution},
      cin          = {A350},
      ddc          = {600},
      cid          = {I:(DE-He78)A350-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39420030},
      pmc          = {pmc:PMC11487170},
      doi          = {10.1038/s41598-024-74324-5},
      url          = {https://inrepo02.dkfz.de/record/294078},
}