Journal Article

DKFZ-2024-02099

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Identification of shared gene expression programs activated in multiple modes of torpor across vertebrate clades.

Weir, K. ; Vega, N. ; Busa, V.DKFZ* ; Sajdak, B. ; Kallestad, L. ; Merriman, D. ; Palczewski, K. ; Carroll, J. ; Blackshaw, S.

2024
Macmillan Publishers Limited, part of Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41598-024-74324-5

Abstract: Torpor encompasses diverse adaptations to extreme environmental stressors such as hibernation, aestivation, brumation, and daily torpor. Here we introduce StrokeofGenus, an analytic pipeline that identifies distinct transcriptomic states and shared gene expression patterns across studies, tissues, and species. We use StrokeofGenus to study multiple and diverse forms of torpor from publicly-available RNA-seq datasets that span eight species and two classes. We identify three transcriptionally distinct states during the cycle of heterothermia: euthermia, torpor, and interbout arousal. We also identify torpor-specific gene expression patterns that are shared both across tissues and between species with over three hundred million years of evolutionary divergence. We further demonstrate the general sharing of gene expression patterns in multiple forms of torpor, implying a common evolutionary origin for this process. Although here we apply StrokeofGenus to analysis of torpor, it can be used to interrogate any other complex physiological processes defined by transient transcriptomic states.

Keyword(s): Animals (MeSH) ; Torpor: genetics (MeSH) ; Vertebrates: genetics (MeSH) ; Transcriptome (MeSH) ; Gene Expression Profiling: methods (MeSH) ; Hibernation: genetics (MeSH) ; Gene Expression Regulation (MeSH) ; Biological Evolution (MeSH)

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Contributing Institute(s):

1. A350 Reguläre Mechanismen der Genexpression (A350)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2024

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