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000294119 0247_ $$2ISSN$$a1600-0625
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000294119 041__ $$aEnglish
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000294119 1001_ $$00000-0002-7973-7608$$aGrönniger, Elke$$b0
000294119 245__ $$aSkin Rejuvenation by Modulation of DNA Methylation.
000294119 260__ $$aOxford$$bBlackwell [[-2008]]$$c2024
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000294119 520__ $$aSkin aging is driven by a complex set of cellular pathways. Among these, epigenetic mechanisms have garnered particular attention, because of their sensitivity to environmental and lifestyle factors. DNA methylation represents the longest known and best understood epigenetic mechanism. We explain how DNA methylation might function as an interface between the environment and the genome of human skin. Exposures to different environmental factors and lifestyles are known to modulate age-related methylation patterns, as illustrated by their effect on DNA methylation clocks. Human skin provides a particularly well-suited tissue for understanding age-related methylation changes and it has been shown recently that modulation of DNA methylation can induce skin rejuvenation. We explain how the use of mildly demethylating agents can be safeguarded to ensure the specific removal of age-related DNA methylation changes. We also identify important areas of future research, leading to a deeper understanding of the mechanisms that drive epigenetic aging and to the development of further refined intervention strategies.
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000294119 650_7 $$2Other$$aDNA methylation
000294119 650_7 $$2Other$$aDNA methylation clock
000294119 650_7 $$2Other$$aaging
000294119 650_7 $$2Other$$adihydromyricetin
000294119 650_7 $$2Other$$arejuvenation
000294119 650_7 $$2Other$$askin
000294119 650_2 $$2MeSH$$aHumans
000294119 650_2 $$2MeSH$$aDNA Methylation
000294119 650_2 $$2MeSH$$aSkin Aging: genetics
000294119 650_2 $$2MeSH$$aRejuvenation: physiology
000294119 650_2 $$2MeSH$$aEpigenesis, Genetic
000294119 650_2 $$2MeSH$$aSkin: metabolism
000294119 7001_ $$00009-0004-2041-5198$$aMax, Heiner$$b1
000294119 7001_ $$0P:(DE-He78)a8d53a8cdc716390a6cbacdead227143$$aLyko, Frank$$b2$$eLast author$$udkfz
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