Journal Article (Review Article)

DKFZ-2024-02122

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Skin Rejuvenation by Modulation of DNA Methylation.

Grönniger, E. ; Max, H. ; Lyko, F. (Last author)DKFZ*

2024
Blackwell [[-2008]] Oxford

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Please use a persistent id in citations: doi:10.1111/exd.70005

Abstract: Skin aging is driven by a complex set of cellular pathways. Among these, epigenetic mechanisms have garnered particular attention, because of their sensitivity to environmental and lifestyle factors. DNA methylation represents the longest known and best understood epigenetic mechanism. We explain how DNA methylation might function as an interface between the environment and the genome of human skin. Exposures to different environmental factors and lifestyles are known to modulate age-related methylation patterns, as illustrated by their effect on DNA methylation clocks. Human skin provides a particularly well-suited tissue for understanding age-related methylation changes and it has been shown recently that modulation of DNA methylation can induce skin rejuvenation. We explain how the use of mildly demethylating agents can be safeguarded to ensure the specific removal of age-related DNA methylation changes. We also identify important areas of future research, leading to a deeper understanding of the mechanisms that drive epigenetic aging and to the development of further refined intervention strategies.

Keyword(s): Humans (MeSH) ; DNA Methylation (MeSH) ; Skin Aging: genetics (MeSH) ; Rejuvenation: physiology (MeSH) ; Epigenesis, Genetic (MeSH) ; Skin: metabolism (MeSH) ; DNA methylation ; DNA methylation clock ; aging ; dihydromyricetin ; rejuvenation ; skin

Note: DKFZ-ZMBH Alliance

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Contributing Institute(s):

1. A130 Epigenetik (A130)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2024

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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