TY  - JOUR
AU  - Grönniger, Elke
AU  - Max, Heiner
AU  - Lyko, Frank
TI  - Skin Rejuvenation by Modulation of DNA Methylation.
JO  - Experimental dermatology
VL  - 33
IS  - 10
SN  - 0906-6705
CY  - Oxford
PB  - Blackwell [[-2008]]
M1  - DKFZ-2024-02122
SP  - e70005
PY  - 2024
N1  - DKFZ-ZMBH Alliance
AB  - Skin aging is driven by a complex set of cellular pathways. Among these, epigenetic mechanisms have garnered particular attention, because of their sensitivity to environmental and lifestyle factors. DNA methylation represents the longest known and best understood epigenetic mechanism. We explain how DNA methylation might function as an interface between the environment and the genome of human skin. Exposures to different environmental factors and lifestyles are known to modulate age-related methylation patterns, as illustrated by their effect on DNA methylation clocks. Human skin provides a particularly well-suited tissue for understanding age-related methylation changes and it has been shown recently that modulation of DNA methylation can induce skin rejuvenation. We explain how the use of mildly demethylating agents can be safeguarded to ensure the specific removal of age-related DNA methylation changes. We also identify important areas of future research, leading to a deeper understanding of the mechanisms that drive epigenetic aging and to the development of further refined intervention strategies.
KW  - Humans
KW  - DNA Methylation
KW  - Skin Aging: genetics
KW  - Rejuvenation: physiology
KW  - Epigenesis, Genetic
KW  - Skin: metabolism
KW  - DNA methylation (Other)
KW  - DNA methylation clock (Other)
KW  - aging (Other)
KW  - dihydromyricetin (Other)
KW  - rejuvenation (Other)
KW  - skin (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39440959
DO  - DOI:10.1111/exd.70005
UR  - https://inrepo02.dkfz.de/record/294119
ER  -