% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Grnniger:294119,
      author       = {E. Grönniger and H. Max and F. Lyko$^*$},
      title        = {{S}kin {R}ejuvenation by {M}odulation of {DNA}
                      {M}ethylation.},
      journal      = {Experimental dermatology},
      volume       = {33},
      number       = {10},
      issn         = {0906-6705},
      address      = {Oxford},
      publisher    = {Blackwell [[-2008]]},
      reportid     = {DKFZ-2024-02122},
      pages        = {e70005},
      year         = {2024},
      note         = {DKFZ-ZMBH Alliance},
      abstract     = {Skin aging is driven by a complex set of cellular pathways.
                      Among these, epigenetic mechanisms have garnered particular
                      attention, because of their sensitivity to environmental and
                      lifestyle factors. DNA methylation represents the longest
                      known and best understood epigenetic mechanism. We explain
                      how DNA methylation might function as an interface between
                      the environment and the genome of human skin. Exposures to
                      different environmental factors and lifestyles are known to
                      modulate age-related methylation patterns, as illustrated by
                      their effect on DNA methylation clocks. Human skin provides
                      a particularly well-suited tissue for understanding
                      age-related methylation changes and it has been shown
                      recently that modulation of DNA methylation can induce skin
                      rejuvenation. We explain how the use of mildly demethylating
                      agents can be safeguarded to ensure the specific removal of
                      age-related DNA methylation changes. We also identify
                      important areas of future research, leading to a deeper
                      understanding of the mechanisms that drive epigenetic aging
                      and to the development of further refined intervention
                      strategies.},
      subtyp        = {Review Article},
      keywords     = {Humans / DNA Methylation / Skin Aging: genetics /
                      Rejuvenation: physiology / Epigenesis, Genetic / Skin:
                      metabolism / DNA methylation (Other) / DNA methylation clock
                      (Other) / aging (Other) / dihydromyricetin (Other) /
                      rejuvenation (Other) / skin (Other)},
      cin          = {A130},
      ddc          = {610},
      cid          = {I:(DE-He78)A130-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39440959},
      doi          = {10.1111/exd.70005},
      url          = {https://inrepo02.dkfz.de/record/294119},
}