guest ::
| Home > Publications database > Skin Rejuvenation by Modulation of DNA Methylation. > print |
| 001 | 294119 | ||
| 005 | 20241024182210.0 | ||
| 024 | 7 | _ | |a 10.1111/exd.70005 |2 doi |
| 024 | 7 | _ | |a pmid:39440959 |2 pmid |
| 024 | 7 | _ | |a 0906-6705 |2 ISSN |
| 024 | 7 | _ | |a 1600-0625 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2024-02122 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Grönniger, Elke |0 0000-0002-7973-7608 |b 0 |
| 245 | _ | _ | |a Skin Rejuvenation by Modulation of DNA Methylation. |
| 260 | _ | _ | |a Oxford |c 2024 |b Blackwell [[-2008]] |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1729770377_24151 |2 PUB:(DE-HGF) |x Review Article |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a DKFZ-ZMBH Alliance |
| 520 | _ | _ | |a Skin aging is driven by a complex set of cellular pathways. Among these, epigenetic mechanisms have garnered particular attention, because of their sensitivity to environmental and lifestyle factors. DNA methylation represents the longest known and best understood epigenetic mechanism. We explain how DNA methylation might function as an interface between the environment and the genome of human skin. Exposures to different environmental factors and lifestyles are known to modulate age-related methylation patterns, as illustrated by their effect on DNA methylation clocks. Human skin provides a particularly well-suited tissue for understanding age-related methylation changes and it has been shown recently that modulation of DNA methylation can induce skin rejuvenation. We explain how the use of mildly demethylating agents can be safeguarded to ensure the specific removal of age-related DNA methylation changes. We also identify important areas of future research, leading to a deeper understanding of the mechanisms that drive epigenetic aging and to the development of further refined intervention strategies. |
| 536 | _ | _ | |a 311 - Zellbiologie und Tumorbiologie (POF4-311) |0 G:(DE-HGF)POF4-311 |c POF4-311 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a DNA methylation |2 Other |
| 650 | _ | 7 | |a DNA methylation clock |2 Other |
| 650 | _ | 7 | |a aging |2 Other |
| 650 | _ | 7 | |a dihydromyricetin |2 Other |
| 650 | _ | 7 | |a rejuvenation |2 Other |
| 650 | _ | 7 | |a skin |2 Other |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a DNA Methylation |2 MeSH |
| 650 | _ | 2 | |a Skin Aging: genetics |2 MeSH |
| 650 | _ | 2 | |a Rejuvenation: physiology |2 MeSH |
| 650 | _ | 2 | |a Epigenesis, Genetic |2 MeSH |
| 650 | _ | 2 | |a Skin: metabolism |2 MeSH |
| 700 | 1 | _ | |a Max, Heiner |0 0009-0004-2041-5198 |b 1 |
| 700 | 1 | _ | |a Lyko, Frank |0 P:(DE-He78)a8d53a8cdc716390a6cbacdead227143 |b 2 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1111/exd.70005 |g Vol. 33, no. 10, p. e70005 |0 PERI:(DE-600)2026228-0 |n 10 |p e70005 |t Experimental dermatology |v 33 |y 2024 |x 0906-6705 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:294119 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)a8d53a8cdc716390a6cbacdead227143 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-311 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Zellbiologie und Tumorbiologie |x 0 |
| 914 | 1 | _ | |y 2024 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2023-08-25 |w ger |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2023-08-25 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-08-25 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2023-08-25 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EXP DERMATOL : 2022 |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-08-25 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-08-25 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2023-08-25 |
| 920 | 2 | _ | |0 I:(DE-He78)A130-20160331 |k A130 |l A130 Epigenetik |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)A130-20160331 |k A130 |l A130 Epigenetik |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)A130-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|