000294388 001__ 294388
000294388 005__ 20241217152854.0
000294388 0247_ $$2doi$$a10.1038/s44318-024-00283-2
000294388 0247_ $$2pmid$$apmid:39482394
000294388 0247_ $$2ISSN$$a0261-4189
000294388 0247_ $$2ISSN$$a1460-2075
000294388 0247_ $$2altmetric$$aaltmetric:169913243
000294388 037__ $$aDKFZ-2024-02217
000294388 041__ $$aEnglish
000294388 082__ $$a570
000294388 1001_ $$0P:(DE-He78)89a6d41f72f195f9f92eb68a4dba2b16$$aHill, Anthony$$b0$$eFirst author$$udkfz
000294388 245__ $$aSingle-nucleus RNA-seq dissection of choroid plexus tumor cell heterogeneity.
000294388 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2024
000294388 3367_ $$2DRIVER$$aarticle
000294388 3367_ $$2DataCite$$aOutput Types/Journal article
000294388 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1734445695_4133
000294388 3367_ $$2BibTeX$$aARTICLE
000294388 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000294388 3367_ $$00$$2EndNote$$aJournal Article
000294388 500__ $$a#EA:A320#LA:A320# / 2024 Dec;43(24):6766-6791
000294388 520__ $$aThe genomic, genetic and cellular events regulating the onset, growth and survival of rare, choroid plexus neoplasms remain poorly understood. Here, we examine the heterogeneity of human choroid plexus tumors by single-nucleus transcriptome analysis of 23,906 cells from four disease-free choroid plexus and eleven choroid plexus tumors. The resulting expression atlas profiles cellular and transcriptional diversity, copy number alterations, and cell-cell interaction networks in normal and cancerous choroid plexus. In choroid plexus tumor epithelial cells, we observe transcriptional changes that correlate with genome-wide methylation profiles. We further characterize tumor type-specific stromal microenvironments that include altered macrophage and mesenchymal cell states, as well as changes in extracellular matrix components. This first single-cell dataset resource from such scarce samples should be valuable for divising therapies against these little-studied neoplasms.
000294388 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
000294388 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000294388 650_7 $$2Other$$aCerebrospinal Fluid (CSF)
000294388 650_7 $$2Other$$aChoroid Plexus Tumors
000294388 650_7 $$2Other$$aSingle Cell RNAseq
000294388 650_7 $$2Other$$aTumor Microenvironment
000294388 7001_ $$0P:(DE-He78)34b3639de467b2c700920d7cbc3d2110$$aOkonechnikov, Konstantin$$b1$$udkfz
000294388 7001_ $$0P:(DE-He78)7fdcafffc4c430027a4e2eb0a198bcfd$$aHerr, Marla Katharina$$b2
000294388 7001_ $$aThomas, Christian$$b3
000294388 7001_ $$0P:(DE-He78)4584d7a74bed56a23f40eb16ff4d2492$$aThongjuea, Supat$$b4$$udkfz
000294388 7001_ $$aHasselblatt, Martin$$b5
000294388 7001_ $$0P:(DE-He78)7de884e25564c58f26d5c8dbed578256$$aPatrizi, Annarita$$b6$$eLast author$$udkfz
000294388 773__ $$0PERI:(DE-600)1467419-1$$a10.1038/s44318-024-00283-2$$n24$$p6766-6791$$tThe EMBO journal$$v43$$x0261-4189$$y2024
000294388 909CO $$ooai:inrepo02.dkfz.de:294388$$pVDB
000294388 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)89a6d41f72f195f9f92eb68a4dba2b16$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000294388 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)34b3639de467b2c700920d7cbc3d2110$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000294388 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7fdcafffc4c430027a4e2eb0a198bcfd$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000294388 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4584d7a74bed56a23f40eb16ff4d2492$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000294388 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7de884e25564c58f26d5c8dbed578256$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000294388 9131_ $$0G:(DE-HGF)POF4-311$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vZellbiologie und Tumorbiologie$$x0
000294388 9141_ $$y2024
000294388 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2023-08-24$$wger
000294388 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEMBO J : 2022$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-24
000294388 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bEMBO J : 2022$$d2023-08-24
000294388 9202_ $$0I:(DE-He78)A320-20160331$$kA320$$lA320 NWG Neuronal signaling and morphogenesis$$x0
000294388 9201_ $$0I:(DE-He78)A320-20160331$$kA320$$lA320 NWG Neuronal signaling and morphogenesis$$x0
000294388 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lB062 Pädiatrische Neuroonkologie$$x1
000294388 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000294388 9200_ $$0I:(DE-He78)A320-20160331$$kA320$$lA320 NWG Neuronal signaling and morphogenesis$$x0
000294388 980__ $$ajournal
000294388 980__ $$aVDB
000294388 980__ $$aI:(DE-He78)A320-20160331
000294388 980__ $$aI:(DE-He78)B062-20160331
000294388 980__ $$aI:(DE-He78)HD01-20160331
000294388 980__ $$aUNRESTRICTED