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@ARTICLE{Hill:294388,
      author       = {A. Hill$^*$ and K. Okonechnikov$^*$ and M. K. Herr$^*$ and
                      C. Thomas and S. Thongjuea$^*$ and M. Hasselblatt and A.
                      Patrizi$^*$},
      title        = {{S}ingle-nucleus {RNA}-seq dissection of choroid plexus
                      tumor cell heterogeneity.},
      journal      = {The EMBO journal},
      volume       = {43},
      number       = {24},
      issn         = {0261-4189},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DKFZ-2024-02217},
      pages        = {6766-6791},
      year         = {2024},
      note         = {#EA:A320#LA:A320# / 2024 Dec;43(24):6766-6791},
      abstract     = {The genomic, genetic and cellular events regulating the
                      onset, growth and survival of rare, choroid plexus neoplasms
                      remain poorly understood. Here, we examine the heterogeneity
                      of human choroid plexus tumors by single-nucleus
                      transcriptome analysis of 23,906 cells from four
                      disease-free choroid plexus and eleven choroid plexus
                      tumors. The resulting expression atlas profiles cellular and
                      transcriptional diversity, copy number alterations, and
                      cell-cell interaction networks in normal and cancerous
                      choroid plexus. In choroid plexus tumor epithelial cells, we
                      observe transcriptional changes that correlate with
                      genome-wide methylation profiles. We further characterize
                      tumor type-specific stromal microenvironments that include
                      altered macrophage and mesenchymal cell states, as well as
                      changes in extracellular matrix components. This first
                      single-cell dataset resource from such scarce samples should
                      be valuable for divising therapies against these
                      little-studied neoplasms.},
      keywords     = {Cerebrospinal Fluid (CSF) (Other) / Choroid Plexus Tumors
                      (Other) / Single Cell RNAseq (Other) / Tumor
                      Microenvironment (Other)},
      cin          = {A320 / B062 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)A320-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39482394},
      doi          = {10.1038/s44318-024-00283-2},
      url          = {https://inrepo02.dkfz.de/record/294388},
}