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@ARTICLE{Zhao:294454,
      author       = {Y. Zhao and Y. Lai and S. K. L. Darweesh and B. R. Bloem
                      and L. Forsgren and J. Hansen and V. A. Katzke$^*$ and G.
                      Masala and S. Sieri and C. Sacerdote and S. Panico and R.
                      Zamora-Ros and M.-J. Sánchez and J. M. Huerta and M.
                      Guevara and A. Vinagre-Aragon and P. Vineis and C. M. Lill
                      and G. W. Miller and S. Peters and R. Vermeulen},
      title        = {{G}ut {M}icrobial {M}etabolites and {F}uture {R}isk of
                      {P}arkinson's {D}isease: {A} {M}etabolome-{W}ide
                      {A}ssociation {S}tudy.},
      journal      = {Movement disorders},
      volume       = {40},
      number       = {3},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DKFZ-2024-02279},
      pages        = {556-560},
      year         = {2025},
      note         = {Volume 40, Issue3, March 2025, Pages 556-560},
      abstract     = {Alterations in gut microbiota are observed in Parkinson's
                      disease (PD). Previous studies on microbiota-derived
                      metabolites in PD were small-scale and post-diagnosis,
                      raising concerns about reverse causality.Our goal was to
                      prospectively investigate the association between plasma
                      microbial metabolites and PD risk within a metabolomics
                      framework.A nested case-control study within the prospective
                      EPIC4PD cohort, measured pre-diagnostic plasma microbial
                      metabolites using untargeted metabolomics.Thirteen microbial
                      metabolites were identified nominally associated with PD
                      risk (P-value < 0.05), including amino acids, bile acid,
                      indoles, and hydroxy acid, although none remained
                      significant after multiple testing correction. Three
                      pathways were implicated in PD risk: valine, leucine, and
                      isoleucine degradation, butanoate metabolism, and propanoate
                      metabolism. PD-associated microbial pathways were more
                      pronounced in men, smokers, and overweight/obese
                      individuals.Changes in microbial metabolites may represent a
                      pre-diagnostic feature of PD. We observed biologically
                      plausible associations between microbial pathways and PD,
                      potentially influenced by individual characteristics. ©
                      2024 The Author(s). Movement Disorders published by Wiley
                      Periodicals LLC on behalf of International Parkinson and
                      Movement Disorder Society.},
      keywords     = {gut‐brain axis; microbial metabolites; Parkinson's
                      disease; pre‐diagnostic biosamples; untargeted
                      metabolomics (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39530417},
      doi          = {10.1002/mds.30054},
      url          = {https://inrepo02.dkfz.de/record/294454},
}