Journal Article

DKFZ-2024-02279

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome-Wide Association Study.

Zhao, Y. ; Lai, Y. ; Darweesh, S. K. L. ; Bloem, B. R. ; Forsgren, L. ; Hansen, J. ; Katzke, V. A.DKFZ* ; Masala, G. ; Sieri, S. ; Sacerdote, C. ; Panico, S. ; Zamora-Ros, R. ; Sánchez, M.-J. ; Huerta, J. M. ; Guevara, M. ; Vinagre-Aragon, A. ; Vineis, P. ; Lill, C. M. ; Miller, G. W. ; Peters, S. ; Vermeulen, R.

2025
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.30054

Abstract: Alterations in gut microbiota are observed in Parkinson's disease (PD). Previous studies on microbiota-derived metabolites in PD were small-scale and post-diagnosis, raising concerns about reverse causality.Our goal was to prospectively investigate the association between plasma microbial metabolites and PD risk within a metabolomics framework.A nested case-control study within the prospective EPIC4PD cohort, measured pre-diagnostic plasma microbial metabolites using untargeted metabolomics.Thirteen microbial metabolites were identified nominally associated with PD risk (P-value < 0.05), including amino acids, bile acid, indoles, and hydroxy acid, although none remained significant after multiple testing correction. Three pathways were implicated in PD risk: valine, leucine, and isoleucine degradation, butanoate metabolism, and propanoate metabolism. PD-associated microbial pathways were more pronounced in men, smokers, and overweight/obese individuals.Changes in microbial metabolites may represent a pre-diagnostic feature of PD. We observed biologically plausible associations between microbial pathways and PD, potentially influenced by individual characteristics. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): gut‐brain axis; microbial metabolites; Parkinson's disease; pre‐diagnostic biosamples; untargeted metabolomics

Note: Volume 40, Issue3, March 2025, Pages 556-560

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Contributing Institute(s):

1. Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2024

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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