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100 1 _ |a Zhao, Yujia
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245 _ _ |a Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome-Wide Association Study.
260 _ _ |a New York, NY
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500 _ _ |a Volume 40, Issue3, March 2025, Pages 556-560
520 _ _ |a Alterations in gut microbiota are observed in Parkinson's disease (PD). Previous studies on microbiota-derived metabolites in PD were small-scale and post-diagnosis, raising concerns about reverse causality.Our goal was to prospectively investigate the association between plasma microbial metabolites and PD risk within a metabolomics framework.A nested case-control study within the prospective EPIC4PD cohort, measured pre-diagnostic plasma microbial metabolites using untargeted metabolomics.Thirteen microbial metabolites were identified nominally associated with PD risk (P-value < 0.05), including amino acids, bile acid, indoles, and hydroxy acid, although none remained significant after multiple testing correction. Three pathways were implicated in PD risk: valine, leucine, and isoleucine degradation, butanoate metabolism, and propanoate metabolism. PD-associated microbial pathways were more pronounced in men, smokers, and overweight/obese individuals.Changes in microbial metabolites may represent a pre-diagnostic feature of PD. We observed biologically plausible associations between microbial pathways and PD, potentially influenced by individual characteristics. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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650 _ 7 |a gut‐brain axis; microbial metabolites; Parkinson's disease; pre‐diagnostic biosamples; untargeted metabolomics
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700 1 _ |a Lai, Yunjia
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700 1 _ |a Darweesh, Sirwan K L
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700 1 _ |a Bloem, Bastiaan R
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700 1 _ |a Sánchez, Maria-Jose
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700 1 _ |a Vinagre-Aragon, Ana
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700 1 _ |a Vineis, Paolo
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700 1 _ |a Lill, Christina M
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700 1 _ |a Miller, Gary W
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700 1 _ |a Peters, Susan
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700 1 _ |a Vermeulen, Roel
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