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@ARTICLE{Baugh:294684,
      author       = {J. N. Baugh and S. Veldhuijzen van Zanten and M. Fiocco and
                      N. Colditz and M. Hoffmann and G. O. Janssens and C.
                      Valentini and D. Hargrave and M. Wiese and A. O. von Bueren
                      and M. Karremann and T. Perwein and G. Nussbaumer and M.
                      Benesch and D. Sturm$^*$ and G. H. Gielen and M. Krause$^*$
                      and M. Eyrich and E. W. Hoving and B. Bison and D. G. van
                      Vuurden and C. M. Kramm},
      title        = {{T}reatment-related survival patterns in diffuse intrinsic
                      pontine glioma using a historical cohort: {A} report from
                      the {E}uropean {S}ociety for {P}ediatric {O}ncology
                      {DIPG}/{DMG} {R}egistry.},
      journal      = {Neuro-oncology advances},
      volume       = {6},
      number       = {1},
      issn         = {2632-2498},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2024-02419},
      pages        = {vdae155},
      year         = {2024},
      abstract     = {Our aim is to investigate the association of treatment with
                      survival in patients with diffuse intrinsic pontine glioma
                      (DIPG) by examining 6 historical treatment paths.We
                      retrospectively analyzed data from 409 patients with
                      radiologically centrally reviewed DIPG, sourced from the
                      German Society of Pediatric Oncology and Hematology HIT-HGG
                      trial database and the SIOPE-DIPG/DMG Registry. Survival
                      outcomes were estimated using the Kaplan-Meier method, and
                      univariable and multivariable Cox proportional hazard models
                      were estimated to study treatment effects.The median overall
                      survival (OS) from diagnosis was 11.2 months $(95\%$
                      confidence interval [CI], 10.5-11.9). Patients who by choice
                      received no frontline treatment had an OS of 3.0 months
                      $(95\%$ CI, 2.0-4.0), while those treated with radiation
                      therapy (RT) alone had a median OS of 10.4 months $(95\%$
                      CI, 9.1-11.8). Those receiving RT combined with chemotherapy
                      had the longest median OS of 11.7 months $(95\%$ CI,
                      10.8-12.6). The median post-progression survival (PPS) was
                      4.1 months $(95\%$ CI, 3.5-4.7). Patients who relapsed and
                      did not receive treatment had a PPS of 2.2 months $(95\%$
                      CI, 1.8-2.6), while those treated with chemotherapy alone
                      had a PPS of 4.4 months $(95\%$ CI, 3.7-5.0), and those who
                      underwent reirradiation, with or without chemotherapy, had
                      the longest survival after relapse of 6.6 months $(95\%$ CI,
                      5.3-8.0). Treatment differences remained significant in
                      multivariable analysis adjusted for age and symptom duration
                      in both diagnosis and relapse setting.This study shows
                      increased survival outcomes associated with radiation and
                      chemotherapy treatment or a combination thereof, at
                      diagnosis and relapse, in a historical DIPG cohort.},
      keywords     = {DIPG (Other) / diffuse intrinsic pontine glioma (Other) /
                      diffuse midline glioma (Other) / historical control (Other)
                      / registry (Other)},
      cin          = {B360 / HD01 / DD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B360-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)DD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39582811},
      pmc          = {pmc:PMC11582646},
      doi          = {10.1093/noajnl/vdae155},
      url          = {https://inrepo02.dkfz.de/record/294684},
}