Journal Article

DKFZ-2024-02419

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Treatment-related survival patterns in diffuse intrinsic pontine glioma using a historical cohort: A report from the European Society for Pediatric Oncology DIPG/DMG Registry.

Baugh, J. N. ; Veldhuijzen van Zanten, S. ; Fiocco, M. ; Colditz, N. ; Hoffmann, M. ; Janssens, G. O. ; Valentini, C. ; Hargrave, D. ; Wiese, M. ; von Bueren, A. O. ; Karremann, M. ; Perwein, T. ; Nussbaumer, G. ; Benesch, M. ; Sturm, D.DKFZ* ; Gielen, G. H. ; Krause, M.DKFZ* ; Eyrich, M. ; Hoving, E. W. ; Bison, B. ; van Vuurden, D. G. ; Kramm, C. M.

2024
Oxford University Press Oxford

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Please use a persistent id in citations: doi:10.1093/noajnl/vdae155

Abstract: Our aim is to investigate the association of treatment with survival in patients with diffuse intrinsic pontine glioma (DIPG) by examining 6 historical treatment paths.We retrospectively analyzed data from 409 patients with radiologically centrally reviewed DIPG, sourced from the German Society of Pediatric Oncology and Hematology HIT-HGG trial database and the SIOPE-DIPG/DMG Registry. Survival outcomes were estimated using the Kaplan-Meier method, and univariable and multivariable Cox proportional hazard models were estimated to study treatment effects.The median overall survival (OS) from diagnosis was 11.2 months (95% confidence interval [CI], 10.5-11.9). Patients who by choice received no frontline treatment had an OS of 3.0 months (95% CI, 2.0-4.0), while those treated with radiation therapy (RT) alone had a median OS of 10.4 months (95% CI, 9.1-11.8). Those receiving RT combined with chemotherapy had the longest median OS of 11.7 months (95% CI, 10.8-12.6). The median post-progression survival (PPS) was 4.1 months (95% CI, 3.5-4.7). Patients who relapsed and did not receive treatment had a PPS of 2.2 months (95% CI, 1.8-2.6), while those treated with chemotherapy alone had a PPS of 4.4 months (95% CI, 3.7-5.0), and those who underwent reirradiation, with or without chemotherapy, had the longest survival after relapse of 6.6 months (95% CI, 5.3-8.0). Treatment differences remained significant in multivariable analysis adjusted for age and symptom duration in both diagnosis and relapse setting.This study shows increased survival outcomes associated with radiation and chemotherapy treatment or a combination thereof, at diagnosis and relapse, in a historical DIPG cohort.

Keyword(s): DIPG ; diffuse intrinsic pontine glioma ; diffuse midline glioma ; historical control ; registry

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Contributing Institute(s):

1. Pädiatrische Gliomforschung (B360)
2. DKTK HD zentral (HD01)
3. DKTK Koordinierungsstelle Dresden (DD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2024

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Web of Science Core Collection

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