% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Skwierawska:294782,
      author       = {D. Skwierawska and S. Bickelhaupt and M. Bachl and R. Janka
                      and M. Murr and F. Gloger and T. A. Kuder$^*$ and M. Zaiss
                      and D. Hadler and M. Uder and F. B. Laun},
      title        = {{R}elevance of {P}rostatic {F}luid on the {A}pparent
                      {D}iffusion {C}oefficient: {A}n {I}nversion {R}ecovery
                      {D}iffusion-{W}eighted {I}maging {I}nvestigation.},
      journal      = {Investigative radiology},
      volume       = {60},
      number       = {6},
      issn         = {0020-9996},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2024-02497},
      pages        = {357-368},
      year         = {2025},
      note         = {2025 Jun 1;60(6):357-368},
      abstract     = {Diffusion-weighted imaging (DWI) is pivotal for prostate
                      magnetic resonance imaging. This is rooted in the generally
                      reduced apparent diffusion coefficient (ADC) observed in
                      prostate cancer in comparison to healthy prostate tissue.
                      This difference originates from microstructural tissue
                      composition changes, including a potentially decreased
                      fluid-containing lumen volume. This study explored the
                      nature of the observed ADC contrast in prostate tissue
                      through inversion recovery-prepared DWI examinations that
                      generated varying levels of fluid suppression.This
                      institutional review board-approved, single-center,
                      prospective study was conducted from 2023 to 2024; all
                      participants underwent magnetic resonance imaging including
                      DWI with b-values of 50 and 800 s/mm2 at 16 inversion times
                      (TI; 60-4000 milliseconds). The measured ADC was interpreted
                      with a 2-compartment model (compartments: tissue and fluid).
                      Descriptive statistics were computed for all analyzed
                      parameters.Twelve healthy male volunteers (45 ± 17 years)
                      and 1 patient with prostate adenocarcinoma (66 years) were
                      evaluated. The ADC map appearance depended heavily on the
                      TI, and we observed a feature-rich ADC(TI) curve. The ADC in
                      the transition zone (TZ) of healthy volunteers increased
                      between TI = 60 milliseconds and approximately 1100
                      milliseconds, then dropped drastically before increasing
                      again, stabilizing at a very high TI. This effect was
                      greatly reduced in the patient's prostate cancer lesion. The
                      2-compartment model described this behavior well. After the
                      inversion, tissue magnetization recovers faster, decreasing
                      its signal contribution in absolute terms and resulting in
                      an increase in the ADC. At the tipping point, the total
                      magnetization is zero at b = 0, when the positive tissue
                      magnetization and still-inverted fluid magnetization cancel
                      out. A small diffusion encoding leads to a positive signal,
                      thus generating an infinite ADC. After the tipping point,
                      the fluid magnetization remains negative and thereby reduces
                      the ADC.Prostate fluid appears to contribute significantly
                      to prostate ADCs. Its contribution could be adjusted by
                      choosing an appropriate inversion recovery preparation,
                      potentially enhancing contrast for prostate cancer lesions.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39621870},
      doi          = {10.1097/RLI.0000000000001139},
      url          = {https://inrepo02.dkfz.de/record/294782},
}