TY  - JOUR
AU  - Macciotta, Alessandra
AU  - Sacerdote, Carlotta
AU  - Giachino, Claudia
AU  - Di Girolamo, Chiara
AU  - Franco, Matteo
AU  - van der Schouw, Yvonne T
AU  - Zamora-Ros, Raul
AU  - Weiderpass, Elisabete
AU  - Domenighetti, Cloé
AU  - Elbaz, Alexis
AU  - Truong, Thérèse
AU  - Agnoli, Claudia
AU  - Bendinelli, Benedetta
AU  - Panico, Salvatore
AU  - Vineis, Paolo
AU  - Christakoudi, Sofia
AU  - Schulze, Matthias B
AU  - Katzke, Verena
AU  - Bajracharya, Rashmita
AU  - Dahm, Christina C
AU  - Dalton, Susanne Oksbjerg
AU  - Colorado-Yohar, Sandra M
AU  - Moreno-Iribas, Conchi
AU  - Etxezarreta, Pilar Amiano
AU  - Sanchez, María José
AU  - Forouhi, Nita G
AU  - Wareham, Nicholas
AU  - Ricceri, Fulvio
TI  - Examining causal relationships between educational attainment and type 2 diabetes using genetic analysis: findings from the EPIC-InterAct study through Mendelian randomisation.
JO  - Journal of epidemiology and community health
VL  - 79
IS  - 5
SN  - 0143-005X
CY  - London
PB  - BMJ Publ. Group
M1  - DKFZ-2024-02628
SP  - 373-379
PY  - 2025
N1  - 2025 Apr 10;79(5):373-379
AB  - Observational studies have shown that more educated people are at lower risk of developing type 2 diabetes (T2D). However, robust study designs are needed to investigate the likelihood that such a relationship is causal. This study used genetic instruments for education to estimate the effect of education on T2D using the Mendelian randomisation (MR) approach.Analyses have been conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study (more than 20 000 individuals), a case-cohort study of T2D nested in the EPIC cohort. Education was measured as Years of Education and Relative Index of Inequality. Prentice-weighted Cox models were performed to estimate the association between education and T2D. One-sample MR analyses investigated whether genetic predisposition towards longer education was associated with risk of T2D and investigated potential mediators of the association.MR estimates indicated a risk reduction of about 15
KW  - DIABETES MELLITUS (Other)
KW  - EDUCATION (Other)
KW  - MENDELIAN RANDOMIZATION ANALYSIS (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39658133
DO  - DOI:10.1136/jech-2024-222734
UR  - https://inrepo02.dkfz.de/record/294921
ER  -