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@ARTICLE{Pfaff:294929,
      author       = {E. Pfaff$^*$ and K. Schramm$^*$ and M. Blattner-Johnson$^*$
                      and B. C. Jones$^*$ and S. Stark$^*$ and G. P.
                      Balasubramanian$^*$ and C. Previti$^*$ and R. J. Autry$^*$
                      and P. Fiesel$^*$ and F. Sahm$^*$ and D. Reuss$^*$ and A.
                      von Deimling$^*$ and C. M. van Tilburg$^*$ and K. W.
                      Pajtler$^*$ and T. Milde$^*$ and U. Dirksen and C. M. Kramm
                      and A. O. von Bueren and M. C. Munthe-Kaas and I. Øra and
                      S. M. Pfister$^*$ and O. Witt$^*$ and D. Jones$^*$},
      title        = {{P}ediatric spinal high-grade glioma in the pediatric
                      precision oncology registry {INFORM}: identification of
                      potential therapeutic targets},
      journal      = {Neuro-oncology advances},
      volume       = {7},
      number       = {1},
      issn         = {2632-2498},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2024-02636},
      pages        = {vdae185},
      year         = {2025},
      note         = {#EA:B360#LA:B360# / Volume 7, Issue 1, January-December
                      2025, vdae185},
      abstract     = {Background: High-grade glioma (HGG) of the spinal cord
                      constitute rare tumors in the pediatric population.
                      Knowledge of the molecular profile of this pediatric HGG
                      (pedHGG) subgroup is limited and the clinical outcome is
                      poor. Therefore, the aim of this study is to provide more
                      profound investigations of molecular characteristics and
                      clinical features of these tumors. Methods: Between 01/2015
                      and 10/2023 seventeen spinal tumors with HGG histology were
                      analyzed by the INFORM precision oncology registry.
                      Comprehensive molecular profiling (including next-generation
                      sequencing approaches and DNA methylation analysis) was
                      performed. Clinical data provided by the treating centers
                      was evaluated regarding treatment approaches and outcome.
                      Results: Subgroup classification based on DNA methylation
                      analysis revealed molecular HGG subgroups in 12/17 cases,
                      while 2/17 were classified as molecular low-grade glioma
                      (LGG) and 3/17 were not unequivocally classifiable. Typical
                      genetic alterations described in pedHGG usually presenting
                      at other localizations were also present in the counterparts
                      located in the spinal cohort. Alterations which might serve
                      as promising target for personalized therapy approaches were
                      identified in a subset of tumors.Conclusion: With this
                      cohort of 12 molecularly confirmed spinal pedHGG cases we
                      provide a compilation of genomic as well as clinical
                      features of this rare subgroup, contributing to a better
                      understanding and eventually to future treatment
                      approaches.},
      cin          = {B360 / B310 / B062 / B300 / HD01 / ED01 / W610},
      ddc          = {610},
      cid          = {I:(DE-He78)B360-20160331 / I:(DE-He78)B310-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)ED01-20160331 /
                      I:(DE-He78)W610-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39896072},
      doi          = {10.1093/noajnl/vdae185},
      url          = {https://inrepo02.dkfz.de/record/294929},
}