Journal Article

DKFZ-2024-02636

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pediatric spinal high-grade glioma in the pediatric precision oncology registry INFORM: identification of potential therapeutic targets

Pfaff, E. (First author)DKFZ* ; Schramm, K.DKFZ* ; Blattner-Johnson, M.DKFZ* ; Jones, B. C.DKFZ* ; Stark, S.DKFZ* ; Balasubramanian, G. P.DKFZ* ; Previti, C.DKFZ* ; Autry, R. J.DKFZ* ; Fiesel, P.DKFZ* ; Sahm, F.DKFZ* ; Reuss, D.DKFZ* ; von Deimling, A.DKFZ* ; van Tilburg, C. M.DKFZ* ; Pajtler, K. W.DKFZ* ; Milde, T.DKFZ* ; Dirksen, U. ; Kramm, C. M. ; von Bueren, A. O. ; Munthe-Kaas, M. C. ; Øra, I. ; Pfister, S. M.DKFZ* ; Witt, O.DKFZ* ; Jones, D. (Last author)DKFZ*

2025
Oxford University Press Oxford

This record in other databases:  

Please use a persistent id in citations: doi:10.1093/noajnl/vdae185

Abstract: Background: High-grade glioma (HGG) of the spinal cord constitute rare tumors in the pediatric population. Knowledge of the molecular profile of this pediatric HGG (pedHGG) subgroup is limited and the clinical outcome is poor. Therefore, the aim of this study is to provide more profound investigations of molecular characteristics and clinical features of these tumors. Methods: Between 01/2015 and 10/2023 seventeen spinal tumors with HGG histology were analyzed by the INFORM precision oncology registry. Comprehensive molecular profiling (including next-generation sequencing approaches and DNA methylation analysis) was performed. Clinical data provided by the treating centers was evaluated regarding treatment approaches and outcome. Results: Subgroup classification based on DNA methylation analysis revealed molecular HGG subgroups in 12/17 cases, while 2/17 were classified as molecular low-grade glioma (LGG) and 3/17 were not unequivocally classifiable. Typical genetic alterations described in pedHGG usually presenting at other localizations were also present in the counterparts located in the spinal cohort. Alterations which might serve as promising target for personalized therapy approaches were identified in a subset of tumors.Conclusion: With this cohort of 12 molecularly confirmed spinal pedHGG cases we provide a compilation of genomic as well as clinical features of this rare subgroup, contributing to a better understanding and eventually to future treatment approaches.

Note: #EA:B360#LA:B360# / Volume 7, Issue 1, January-December 2025, vdae185

---

Contributing Institute(s):

1. Pädiatrische Gliomforschung (B360)
2. KKE Pädiatrische Onkologie (B310)
3. B062 Pädiatrische Neuroonkologie (B062)
4. KKE Neuropathologie (B300)
5. DKTK HD zentral (HD01)
6. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)
7. Core Facility Omics IT (W610)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2024

---

Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Web of Science Core Collection

---