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@ARTICLE{AguadoBarrera:296085,
      author       = {M. E. Aguado-Barrera and C. Lopez-Pleguezuelos and A.
                      Gómez-Caamaño and P. Calvo-Crespo and B.
                      Taboada-Valladares and D. Azria and P. Boisselier and E.
                      Briers and C. Chan and J. Chang-Claude$^*$ and C.
                      Coedo-Costa and A. Crujeiras-González and J. J. Cuaron and
                      G. Defraene and R. M. Elliott and C. Faivre-Finn and M.
                      Franceschini and O. Fuentes-Rios and J. Galego-Carro and S.
                      Gutiérrez-Enríquez and P. Heumann$^*$ and D. S. Higginson
                      and K. Johnson and M. Lambrecht and P. Lang and Y. Lievens
                      and M. Mollà and M. Ramos and T. Rancati and T. Rattay and
                      A. Rimner and B. S. Rosenstein and C. Sangalli and P.
                      Seibold$^*$ and E. Sperk and H. Stobart and P. Symonds and
                      C. J. Talbot and K. Vandecasteele and L. Veldeman and T.
                      Ward and A. Webb and D. Woolf and D. de Ruysscher and C. M.
                      L. West and A. Vega},
      collaboration = {R. Consortium},
      title        = {{P}rofessional-patient discrepancies in assessing lung
                      cancer radiotherapy symptoms: {A}n international multicentre
                      study.},
      journal      = {Lung cancer},
      volume       = {199},
      issn         = {0169-5002},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-00033},
      pages        = {108072},
      year         = {2025},
      abstract     = {We investigate discrepancies in the assessment of
                      treatment-related symptoms in lung cancer between healthcare
                      professionals and patients, and factors contributing to
                      these discrepancies.Data from 515 participants in the
                      REQUITE study were analysed. Five symptoms (cough, dyspnoea,
                      bronchopulmonary haemorrhage, chest wall pain, dysphagia)
                      were evaluated both before and after radiotherapy. Agreement
                      between healthcare professionals and people with lung cancer
                      was quantified using Gwet's-AC2 coefficient. The influence
                      of clinical variables, comorbidities, and quality-of-life
                      outcomes on agreement was examined through stratified
                      analyses.We found varying levels of agreement between
                      healthcare professionals and people with lung cancer.
                      Bronchopulmonary haemorrhage and dysphagia exhibited very
                      good agreement (meanAC2 > 0.81), while cough and chest wall
                      pain showed substantial agreement (meanAC2 = 0.64 and 0.76,
                      respectively). Dyspnoea had the lowest agreement (meanAC2 =
                      0.59), with prior chemotherapy significantly reducing
                      agreement levels. Chronic obstructive pulmonary disease
                      (COPD) and early cancer stages also contributed to
                      discrepancies in dyspnoea assessments. Regarding
                      quality-of-life, the most relevant factor was fatigue, which
                      reduced agreement in the assessment of dyspnoea (AC2 = 0.55
                      vs 0.70), dysphagia (AC2 = 0.48 vs 0.69), cough (AC2 = 0.58
                      vs 0.82), and chest wall pain (AC2 = 0.77 vs 0.91).Our
                      findings indicate strong alignment between healthcare
                      professionals' and people with lung cancer evaluations of
                      observable treatment-related symptoms, but less consistency
                      for subjective symptoms such as dyspnoea. Factors such as
                      prior chemotherapy, COPD, and cancer stage should be
                      considered when interpreting symptom assessments.
                      Furthermore, our study underscores the importance of
                      integrating quality-of-life considerations, particularly
                      fatigue, into symptom evaluations to mitigate potential
                      biases in symptom perception.},
      keywords     = {Correlation measures (Other) / Fatigue (Other) / Lung
                      cancer (Other) / Patient reported outcome measures (Other) /
                      Quality of life (Other) / Radiation effects (Other) /
                      Symptom assessment (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39740425},
      doi          = {10.1016/j.lungcan.2024.108072},
      url          = {https://inrepo02.dkfz.de/record/296085},
}