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@ARTICLE{Liu:298231,
      author       = {J. Liu$^*$ and E. Kharazmi$^*$ and Q. Liang$^*$ and Y.
                      Chen$^*$ and J. Sundquist and K. Sundquist and M.
                      Fallah$^*$},
      title        = {{M}aternal weight during pregnancy and risk of childhood
                      acute lymphoblastic leukemia in offspring.},
      journal      = {Leukemia},
      volume       = {39},
      number       = {3},
      issn         = {0887-6924},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-00238},
      pages        = {590-598},
      year         = {2025},
      note         = {#EA:C120#LA:C120# / 2025 Mar;39(3):590-598},
      abstract     = {In addition to biological factors, maternal exposures
                      during pregnancy can contribute to leukemogenesis in
                      offspring. We conducted a population-based cohort study in
                      Sweden to investigate the association between risk of acute
                      lymphoblastic leukemia (ALL) in offspring and maternal
                      anthropometrics during pregnancy. A total of 2,961,435
                      live-born singletons during 1983-2018 were followed from
                      birth to ALL diagnosis, end of age 18, or end of 2018. 1388
                      children were diagnosed with ALL $(55.6\%$ boys). We
                      observed an increased risk of ALL among daughters of
                      overweight/obese mothers in early pregnancy [Body mass index
                      (BMI) ≥ 25 kg/m2; Standardized incidence ratio (SIR) =
                      1.4, $95\%$ CI: 1.2-1.6] compared with the risk in daughters
                      of mothers with normal BMI. This association was not found
                      in their sons (SIR = 1.0, $95\%$ CI: 0.9-1.1). Similar
                      results were found for the association between ALL and
                      maternal BMI before delivery. We did not find an association
                      between low or high gestational weight gain (GWG) and risk
                      of ALL (both SIRs = 1.0) in male/female offspring. These
                      suggest that maternal overweight/obesity are important risk
                      factors for childhood ALL in daughters, whereas GWG is not
                      associated with risk of ALL. Further research on this
                      mother-daughter association may shed light on a possible sex
                      hormone/chromosome-related etiology of ALL.},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39865137},
      doi          = {10.1038/s41375-025-02517-6},
      url          = {https://inrepo02.dkfz.de/record/298231},
}