Journal Article

DKFZ-2025-00238

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Maternal weight during pregnancy and risk of childhood acute lymphoblastic leukemia in offspring.

Liu, J. (First author)DKFZ* ; Kharazmi, E.DKFZ* ; Liang, Q.DKFZ* ; Chen, Y.DKFZ* ; Sundquist, J. ; Sundquist, K. ; Fallah, M. (Last author)DKFZ*

2025
Springer Nature London

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Please use a persistent id in citations: doi:10.1038/s41375-025-02517-6

Abstract: In addition to biological factors, maternal exposures during pregnancy can contribute to leukemogenesis in offspring. We conducted a population-based cohort study in Sweden to investigate the association between risk of acute lymphoblastic leukemia (ALL) in offspring and maternal anthropometrics during pregnancy. A total of 2,961,435 live-born singletons during 1983-2018 were followed from birth to ALL diagnosis, end of age 18, or end of 2018. 1388 children were diagnosed with ALL (55.6% boys). We observed an increased risk of ALL among daughters of overweight/obese mothers in early pregnancy [Body mass index (BMI) ≥ 25 kg/m2; Standardized incidence ratio (SIR) = 1.4, 95% CI: 1.2-1.6] compared with the risk in daughters of mothers with normal BMI. This association was not found in their sons (SIR = 1.0, 95% CI: 0.9-1.1). Similar results were found for the association between ALL and maternal BMI before delivery. We did not find an association between low or high gestational weight gain (GWG) and risk of ALL (both SIRs = 1.0) in male/female offspring. These suggest that maternal overweight/obesity are important risk factors for childhood ALL in daughters, whereas GWG is not associated with risk of ALL. Further research on this mother-daughter association may shed light on a possible sex hormone/chromosome-related etiology of ALL.

Note: #EA:C120#LA:C120# / 2025 Mar;39(3):590-598

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Contributing Institute(s):

1. Primäre Krebsprävention (C120)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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