%0 Journal Article
%A Blum, Belinda
%A Dachtler, Victoria
%A Feldmann, Angelika
%T Enhancer-dependent gene regulation in space, time, and malignancies.
%J International journal of cancer
%V 158
%N 2
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2025-00267
%P 357–367
%D 2026
%Z #EA:B460#LA:B460# /  2026 Jan 15;158(2):357-367
%X Control of cell-type-specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells. In this review, we provide an overview of our current understanding of enhancer-driven gene regulation and discuss how this activity may be integrated across time, followed by epigenetic and structural alterations of enhancers in cancers.
%K cancer epigenetics (Other)
%K distal regulatory elements (Other)
%K enhancer hijacking (Other)
%K genome structure (Other)
%K temporal dynamics (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39887412
%R 10.1002/ijc.35350
%U https://inrepo02.dkfz.de/record/298411