Journal Article (Review Article)

DKFZ-2025-00267

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Enhancer-dependent gene regulation in space, time, and malignancies.

Blum, B. (First author)DKFZ* ; Dachtler, V.DKFZ* ; Feldmann, A. (Last author)DKFZ*

2026
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.35350

Abstract: Control of cell-type-specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells. In this review, we provide an overview of our current understanding of enhancer-driven gene regulation and discuss how this activity may be integrated across time, followed by epigenetic and structural alterations of enhancers in cancers.

Keyword(s): cancer epigenetics ; distal regulatory elements ; enhancer hijacking ; genome structure ; temporal dynamics

Note: #EA:B460#LA:B460# / 2026 Jan 15;158(2):357-367

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Contributing Institute(s):

1. NWG Mechanismen der Genomkontrolle (B460)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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