TY  - JOUR
AU  - Blum, Belinda
AU  - Dachtler, Victoria
AU  - Feldmann, Angelika
TI  - Enhancer-dependent gene regulation in space, time, and malignancies.
JO  - International journal of cancer
VL  - 158
IS  - 2
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2025-00267
SP  - 357–367
PY  - 2026
N1  - #EA:B460#LA:B460# /  2026 Jan 15;158(2):357-367
AB  - Control of cell-type-specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells. In this review, we provide an overview of our current understanding of enhancer-driven gene regulation and discuss how this activity may be integrated across time, followed by epigenetic and structural alterations of enhancers in cancers.
KW  - cancer epigenetics (Other)
KW  - distal regulatory elements (Other)
KW  - enhancer hijacking (Other)
KW  - genome structure (Other)
KW  - temporal dynamics (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39887412
DO  - DOI:10.1002/ijc.35350
UR  - https://inrepo02.dkfz.de/record/298411
ER  -