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@ARTICLE{Blum:298411,
      author       = {B. Blum$^*$ and V. Dachtler$^*$ and A. Feldmann$^*$},
      title        = {{E}nhancer-dependent gene regulation in space, time, and
                      malignancies.},
      journal      = {International journal of cancer},
      volume       = {158},
      number       = {2},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2025-00267},
      pages        = {357–367},
      year         = {2026},
      note         = {#EA:B460#LA:B460# / 2026 Jan 15;158(2):357-367},
      abstract     = {Control of cell-type-specific gene activation requires the
                      coordinated activity of distal regulatory elements,
                      including enhancers, whose inputs must be temporally
                      integrated. Dysregulation of this regulatory capacity, such
                      as aberrant usage of enhancers, can result in malignant
                      transformation of cells. In this review, we provide an
                      overview of our current understanding of enhancer-driven
                      gene regulation and discuss how this activity may be
                      integrated across time, followed by epigenetic and
                      structural alterations of enhancers in cancers.},
      subtyp        = {Review Article},
      keywords     = {cancer epigenetics (Other) / distal regulatory elements
                      (Other) / enhancer hijacking (Other) / genome structure
                      (Other) / temporal dynamics (Other)},
      cin          = {B460},
      ddc          = {610},
      cid          = {I:(DE-He78)B460-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39887412},
      doi          = {10.1002/ijc.35350},
      url          = {https://inrepo02.dkfz.de/record/298411},
}