TY  - JOUR
AU  - Mokry, Theresa
AU  - Pantke, Judith
AU  - Kauczor, Hans-Ulrich
AU  - Laun, Frederik B
AU  - Schlemmer, Heinz-Peter
AU  - Kuder, Tristan Anselm
AU  - Bickelhaupt, Sebastian
TI  - Influence of field strength on quantitative parameters and feature stability in the assessment of the ovaries using 1.5-T and 3-T MRI.
JO  - Acta radiologica
VL  - 66
IS  - 5
SN  - 0567-8056
CY  - London
PB  - Sage
M1  - DKFZ-2025-00295
SP  - 512-520
PY  - 2025
N1  - 2025 May;66(5):512-520
AB  - Little is known of the influence of scanner field strength on quantitative diffusivity variables, especially kurtosis in healthy ovaries.To evaluate the influence of scanner field strength on quantitative diffusion variables in pelvic MRI of the ovaries.This prospective, single-centre study consisted of repeated 1.5-T and 3-T examinations in 30 female volunteers (mean age=27.9 years, age range=20.3-45.2 years) from July 2017 to September 2019. Multi b-value DWI 0, 50, 100, 800, 1500, 2000 s/mm2 was acquired over three timepoints during the menstrual cycle. Ovaries were segmented at b = 1500 s/mm2. Median apparent diffusion coefficient (ADC) and advanced kurtosis parameters Dapp and Kapp were calculated. Statistical analysis was performed with the variations of diffusivity variables being compared between 1.5-T and 3-T MRI using a Mann-Whitney rank-sum test.Median ADC and Dapp (µm²/ms) did not statistically differ. Median ADC were 1.509 (range=1.371-1.610), 1.619 (range=1.463-1.747), and 1.511 (range=1.423-1.639) at 1.5 T; 1.542 (range=1.428-1.682), 1.658 (range=1.510-1.806), and 1.572 (range=1.455-1.709) at 3 T (P = 0.14, 0.19, and 0.07), whereas median Dapp were 2.024 (range=1.913-2.152), 2.192 (range=2.010-2.327), and 2.045 (range=1.958-2.170) at 1.5 T; 2.013 (range=1.952-2.188), 2.179 (range=2.018-2.327), and 2.082 (range=1.959-2.194) at 3 T (P = 0.77, 0.99, and 0.34) for timepoints 1, 2, and 3, respectively. Statistical comparison of Kapp revealed significant differences for all timepoints: 0.629 (range=0.595-0.652), 0.604 (range=0.574-0.651), and 0.622 (range=0.581-0.664) at 1.5 T; 0.601 (range=0.563-0.626), 0.567 (range=0.526-0.633), and 0.599 (range=0.541-0.650) at 3 T (P < 0.001, 0.005, and 0.03).Diffusivity mapping in the ovaries provides similar absolute median diffusion values, but statistically significant differences in absolute kurtosis values between 1.5 T and 3 T.
KW  - Genital (Other)
KW  - adults (Other)
KW  - magnetic resonance diffusion/perfusion (Other)
KW  - ovaries (Other)
KW  - reproductive (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39905712
DO  - DOI:10.1177/02841851241313021
UR  - https://inrepo02.dkfz.de/record/298578
ER  -