Journal Article

DKFZ-2025-00295

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Influence of field strength on quantitative parameters and feature stability in the assessment of the ovaries using 1.5-T and 3-T MRI.

Mokry, T. (First author)DKFZ* ; Pantke, J. ; Kauczor, H.-U. ; Laun, F. B. ; Schlemmer, H.-P.DKFZ* ; Kuder, T. A.DKFZ* ; Bickelhaupt, S.

2025
Sage London

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Please use a persistent id in citations: doi:10.1177/02841851241313021

Abstract: Little is known of the influence of scanner field strength on quantitative diffusivity variables, especially kurtosis in healthy ovaries.To evaluate the influence of scanner field strength on quantitative diffusion variables in pelvic MRI of the ovaries.This prospective, single-centre study consisted of repeated 1.5-T and 3-T examinations in 30 female volunteers (mean age=27.9 years, age range=20.3-45.2 years) from July 2017 to September 2019. Multi b-value DWI 0, 50, 100, 800, 1500, 2000 s/mm2 was acquired over three timepoints during the menstrual cycle. Ovaries were segmented at b = 1500 s/mm2. Median apparent diffusion coefficient (ADC) and advanced kurtosis parameters Dapp and Kapp were calculated. Statistical analysis was performed with the variations of diffusivity variables being compared between 1.5-T and 3-T MRI using a Mann-Whitney rank-sum test.Median ADC and Dapp (µm²/ms) did not statistically differ. Median ADC were 1.509 (range=1.371-1.610), 1.619 (range=1.463-1.747), and 1.511 (range=1.423-1.639) at 1.5 T; 1.542 (range=1.428-1.682), 1.658 (range=1.510-1.806), and 1.572 (range=1.455-1.709) at 3 T (P = 0.14, 0.19, and 0.07), whereas median Dapp were 2.024 (range=1.913-2.152), 2.192 (range=2.010-2.327), and 2.045 (range=1.958-2.170) at 1.5 T; 2.013 (range=1.952-2.188), 2.179 (range=2.018-2.327), and 2.082 (range=1.959-2.194) at 3 T (P = 0.77, 0.99, and 0.34) for timepoints 1, 2, and 3, respectively. Statistical comparison of Kapp revealed significant differences for all timepoints: 0.629 (range=0.595-0.652), 0.604 (range=0.574-0.651), and 0.622 (range=0.581-0.664) at 1.5 T; 0.601 (range=0.563-0.626), 0.567 (range=0.526-0.633), and 0.599 (range=0.541-0.650) at 3 T (P < 0.001, 0.005, and 0.03).Diffusivity mapping in the ovaries provides similar absolute median diffusion values, but statistically significant differences in absolute kurtosis values between 1.5 T and 3 T.

Keyword(s): Genital ; adults ; magnetic resonance diffusion/perfusion ; ovaries ; reproductive

Note: 2025 May;66(5):512-520

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Contributing Institute(s):

1. E010 Radiologie (E010)
2. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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