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000298613 1001_ $$00000-0001-8899-9522$$aVidal-Vázquez, Nicolás$$b0
000298613 245__ $$aA single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula.
000298613 260__ $$aLondon$$bNature Publ. Group$$c2025
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000298613 520__ $$aThe retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. In recent years, single-cell RNA sequencing studies have uncovered cellular diversity in the retina of a variety of species, providing new insights on retinal evolution and development. However, similar data in cartilaginous fishes, the sister group to all other extant jawed vertebrates, are still lacking. Here, we present a single-nucleus RNA sequencing atlas of the postnatal retina of the catshark Scyliorhinus canicula, consisting of the expression profiles for 17,438 individual cells from three female, juvenile catshark specimens. Unsupervised clustering revealed 22 distinct cell types comprising all major retinal cell classes, as well as retinal progenitor cells (whose presence reflects the persistence of proliferative activity in postnatal stages in sharks) and oligodendrocytes. Thus, our dataset serves as a foundation for further studies on the development and function of the catshark retina. Moreover, integration of our atlas with data from other species will allow for a better understanding of vertebrate retinal evolution.
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000298613 650_2 $$2MeSH$$aAnimals
000298613 650_2 $$2MeSH$$aSharks: genetics
000298613 650_2 $$2MeSH$$aRetina: metabolism
000298613 650_2 $$2MeSH$$aRetina: cytology
000298613 650_2 $$2MeSH$$aFemale
000298613 650_2 $$2MeSH$$aSequence Analysis, RNA
000298613 650_2 $$2MeSH$$aSingle-Cell Analysis
000298613 7001_ $$aHernández-Núñez, Ismael$$b1
000298613 7001_ $$00009-0005-4095-7637$$aCarballo-Pacoret, Pablo$$b2
000298613 7001_ $$aSalisbury, Sarah$$b3
000298613 7001_ $$aVillamayor, Paula R$$b4
000298613 7001_ $$aHervas-Sotomayor, Francisca$$b5
000298613 7001_ $$aYuan, Xuefei$$b6
000298613 7001_ $$aLamanna, Francesco$$b7
000298613 7001_ $$00000-0002-4505-4825$$aSchneider, Céline$$b8
000298613 7001_ $$0P:(DE-He78)4556f6197ebc4a0679f8cf26a6d9c119$$aSchmidt, Julia$$b9$$udkfz
000298613 7001_ $$aMazan, Sylvie$$b10
000298613 7001_ $$00000-0001-7563-839X$$aKaessmann, Henrik$$b11
000298613 7001_ $$00000-0002-3196-7682$$aAdrio, Fátima$$b12
000298613 7001_ $$00000-0002-9616-5912$$aRobledo, Diego$$b13
000298613 7001_ $$00000-0002-7507-080X$$aBarreiro-Iglesias, Antón$$b14
000298613 7001_ $$00000-0001-6136-7605$$aCandal, Eva$$b15
000298613 773__ $$0PERI:(DE-600)2775191-0$$a10.1038/s41597-025-04547-2$$gVol. 12, no. 1, p. 228$$n1$$p228$$tScientific data$$v12$$x2052-4436$$y2025
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