Journal Article

DKFZ-2025-00313

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula.

Vidal-Vázquez, N. ; Hernández-Núñez, I. ; Carballo-Pacoret, P. ; Salisbury, S. ; Villamayor, P. R. ; Hervas-Sotomayor, F. ; Yuan, X. ; Lamanna, F. ; Schneider, C. ; Schmidt, J.DKFZ* ; Mazan, S. ; Kaessmann, H. ; Adrio, F. ; Robledo, D. ; Barreiro-Iglesias, A. ; Candal, E.

2025
Nature Publ. Group London

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Please use a persistent id in citations: doi:10.1038/s41597-025-04547-2

Abstract: The retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. In recent years, single-cell RNA sequencing studies have uncovered cellular diversity in the retina of a variety of species, providing new insights on retinal evolution and development. However, similar data in cartilaginous fishes, the sister group to all other extant jawed vertebrates, are still lacking. Here, we present a single-nucleus RNA sequencing atlas of the postnatal retina of the catshark Scyliorhinus canicula, consisting of the expression profiles for 17,438 individual cells from three female, juvenile catshark specimens. Unsupervised clustering revealed 22 distinct cell types comprising all major retinal cell classes, as well as retinal progenitor cells (whose presence reflects the persistence of proliferative activity in postnatal stages in sharks) and oligodendrocytes. Thus, our dataset serves as a foundation for further studies on the development and function of the catshark retina. Moreover, integration of our atlas with data from other species will allow for a better understanding of vertebrate retinal evolution.

Keyword(s): Animals (MeSH) ; Sharks: genetics (MeSH) ; Retina: metabolism (MeSH) ; Retina: cytology (MeSH) ; Female (MeSH) ; Sequence Analysis, RNA (MeSH) ; Single-Cell Analysis (MeSH)

Note: DKFZ-ZMBH Alliance

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Contributing Institute(s):

1. Stressinduzierte Aktivierung von Hämatopeotischen Stammzellen (A011)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2025

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