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@ARTICLE{Wiala:298889,
      author       = {A. Wiala and K. G. Elhage and A. Leung and A. T. Young and
                      M. Gregory and I. Adrianto and L. Zhou and Q.-S. Mi and S.
                      Kumar and F. Orcales and S. Yeroushalmi and K. Haran and J.
                      Liu and H. B. Naik and W. Liao and C. Posch$^*$},
      title        = {{P}atients with {PSO}riasis and {S}uppurative
                      {H}idradenitis ({PSO}-{SH}) share genetic risk factors and
                      are at risk of increased morbidity.},
      journal      = {Journal of the American Academy of Dermatology},
      volume       = {92},
      number       = {6},
      issn         = {0190-9622},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-00334},
      pages        = {1303-1311},
      year         = {2025},
      note         = {2025 Jun;92(6):1303-1311},
      abstract     = {Select patients are diagnosed with both, psoriasis (PSO)
                      and hidradenitis suppurativa (HS), leading to a unique
                      disease pattern. Genetic risk factors remain
                      unidentified.The study harnessed an international collection
                      of patients with psoriasis and HS (PSO-SH). Clinical and
                      genetic data was collected and analyzed.87 PSO-SH patients
                      $(70\%$ female) were identified. They had a high number of
                      comorbidities $(89\%),$ and worse general physical health
                      compared to PSO-only (OR 3.09 $95\%CI$ 1.56-6.12) or HS-only
                      (OR 2.5, $95\%CI$ 1.23-5.00) patients. PSO-SH patients were
                      at significantly higher risk of having Crohn's disease (OR
                      4.6-11.9; $95\%$ CI). Data revealed the highest overall
                      genetic risk score for PSO-SH patients (PSO-PRS; 108.22),
                      followed by PSO (101.18), HS (99.84), and healthy controls
                      (98.58). High non-HLA scores were associated with an
                      increased risk for developing both psoriasis and HS,
                      indicating a distinct biological profile compared to HS-only
                      and PSO-only individuals.Some clinical information was
                      collected retrospectively.This study highlights a shared
                      genetic susceptibility of HS and psoriasis at non-HLA loci.
                      Recognizing PSO-SH patients as a distinct patient group with
                      high morbidity and increased risk for developing Crohn's
                      disease will help to improve patient management.},
      keywords     = {HLA (Other) / Hidradenitis suppurativa (Other) / PSO-SH
                      (Other) / Psoriasis (Other) / co-occurrence (Other) /
                      genetics (Other) / non-HLA (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39929305},
      doi          = {10.1016/j.jaad.2025.02.015},
      url          = {https://inrepo02.dkfz.de/record/298889},
}