Journal Article

DKFZ-2025-00334

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Patients with PSOriasis and Suppurative Hidradenitis (PSO-SH) share genetic risk factors and are at risk of increased morbidity.

Wiala, A. ; Elhage, K. G. ; Leung, A. ; Young, A. T. ; Gregory, M. ; Adrianto, I. ; Zhou, L. ; Mi, Q.-S. ; Kumar, S. ; Orcales, F. ; Yeroushalmi, S. ; Haran, K. ; Liu, J. ; Naik, H. B. ; Liao, W. ; Posch, C.DKFZ*

2025
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jaad.2025.02.015

Abstract: Select patients are diagnosed with both, psoriasis (PSO) and hidradenitis suppurativa (HS), leading to a unique disease pattern. Genetic risk factors remain unidentified.The study harnessed an international collection of patients with psoriasis and HS (PSO-SH). Clinical and genetic data was collected and analyzed.87 PSO-SH patients (70% female) were identified. They had a high number of comorbidities (89%), and worse general physical health compared to PSO-only (OR 3.09 95%CI 1.56-6.12) or HS-only (OR 2.5, 95%CI 1.23-5.00) patients. PSO-SH patients were at significantly higher risk of having Crohn's disease (OR 4.6-11.9; 95% CI). Data revealed the highest overall genetic risk score for PSO-SH patients (PSO-PRS; 108.22), followed by PSO (101.18), HS (99.84), and healthy controls (98.58). High non-HLA scores were associated with an increased risk for developing both psoriasis and HS, indicating a distinct biological profile compared to HS-only and PSO-only individuals.Some clinical information was collected retrospectively.This study highlights a shared genetic susceptibility of HS and psoriasis at non-HLA loci. Recognizing PSO-SH patients as a distinct patient group with high morbidity and increased risk for developing Crohn's disease will help to improve patient management.

Keyword(s): HLA ; Hidradenitis suppurativa ; PSO-SH ; Psoriasis ; co-occurrence ; genetics ; non-HLA

Note: 2025 Jun;92(6):1303-1311

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Contributing Institute(s):

1. DKTK Koordinierungsstelle München (MU01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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