000298935 001__ 298935
000298935 005__ 20250425093418.0
000298935 0247_ $$2doi$$a10.1093/stmcls/sxae084
000298935 0247_ $$2pmid$$apmid:39949042
000298935 0247_ $$2ISSN$$a1066-5099
000298935 0247_ $$2ISSN$$a0737-1454
000298935 0247_ $$2ISSN$$a1549-4918
000298935 037__ $$aDKFZ-2025-00369
000298935 041__ $$aEnglish
000298935 082__ $$a610
000298935 1001_ $$0P:(DE-He78)d06e5bb2d0828caa2be79a51825e84e1$$aPagliari, Francesca$$b0$$eFirst author$$udkfz
000298935 245__ $$aRaman Spectroscopies for Cancer Research and Clinical Applications: a Focus on Cancer Stem Cells.
000298935 260__ $$aOxford$$bOxford University Press$$c2025
000298935 3367_ $$2DRIVER$$aarticle
000298935 3367_ $$2DataCite$$aOutput Types/Journal article
000298935 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1745566417_21579
000298935 3367_ $$2BibTeX$$aARTICLE
000298935 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000298935 3367_ $$00$$2EndNote$$aJournal Article
000298935 500__ $$a#EA:E041# / Volume 43, Issue 4, April 2025, sxae084
000298935 520__ $$aOver the last two decades, research has increasingly focused on Cancer Stem Cells (CSCs), considered responsible for tumor formation, resistance to therapies, and relapse. The traditional 'static' CSC model used to describe tumor heterogeneity has been challenged by the evidence of CSC dynamic nature and plasticity. A comprehensive understanding of the mechanisms underlying this plasticity, and the capacity to unambiguously identify cancer markers to precisely target CSCs are crucial aspects for advancing cancer research and introducing more effective treatment strategies. In this context, Raman spectroscopy (RS) and specific Raman schemes, including CARS, SRS, SERS, have emerged as innovative tools for molecular analyses both in vitro and in vivo. In fact, these techniques have demonstrated considerable potential in the field of cancer detection, as well as in intraoperative settings, thanks to their label-free nature and minimal invasiveness. However, the RS integration in pre-clinical and clinical applications, particularly in the CSC field, remains limited. This review provides a concise overview of the historical development of RS and its advantages. Then, after introducing the CSC features and the challenges in targeting them with traditional methods, we review and discuss the current literature about the application of RS for revealing and characterizing CSCs and their inherent plasticity, including a brief paragraph about the integration of artificial intelligence with RS. By providing the possibility to better characterize the cellular diversity in their microenvironment, RS could revolutionize current diagnostic and therapeutic approaches, enabling early identification of CSCs and facilitating the development of personalized treatment strategies.
000298935 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000298935 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000298935 650_7 $$2Other$$aCancer Stem Cells
000298935 650_7 $$2Other$$aCancer detection
000298935 650_7 $$2Other$$aCancer markers
000298935 650_7 $$2Other$$aLabel-free imaging
000298935 650_7 $$2Other$$aRaman spectroscopy
000298935 7001_ $$aTirinato, Luca$$b1
000298935 7001_ $$00000-0001-9826-2129$$aDi Fabrizio, Enzo$$b2
000298935 773__ $$0PERI:(DE-600)2030643-X$$a10.1093/stmcls/sxae084$$gp. sxae084$$n4$$psxae084$$tStem cells$$v43$$x1066-5099$$y2025
000298935 909CO $$ooai:inrepo02.dkfz.de:298935$$pVDB
000298935 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d06e5bb2d0828caa2be79a51825e84e1$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000298935 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000298935 9141_ $$y2025
000298935 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2024-12-18$$wger
000298935 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSTEM CELLS : 2022$$d2024-12-18
000298935 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bSTEM CELLS : 2022$$d2024-12-18
000298935 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lMed. Physik in der Radioonkologie$$x0
000298935 9200_ $$0I:(DE-He78)E041-20160331$$kE041$$lMed. Physik in der Radioonkologie$$x0
000298935 980__ $$ajournal
000298935 980__ $$aVDB
000298935 980__ $$aI:(DE-He78)E041-20160331
000298935 980__ $$aUNRESTRICTED