Journal Article (Review Article)

DKFZ-2025-00372

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Scientific approaches to defining HPV vaccine-induced protective immunity.

Lehtinen, M. ; van Damme, P. ; Beddows, S. ; Pinto, L. A. ; Mariz, F.DKFZ* ; Gray, P. ; Dillner, J.

2025
Wiley-Liss Bognor Regis

Abstract: Seventeen years after the licensure of prophylactic human papillomavirus (HPV) L1 virus-like-particle vaccines, a defined antibody level that correlates with vaccine-induced protection against HPV infections and associated neoplasia is missing. In contrast, correlates of protection have been defined for many viral vaccines, including for the hepatitis B virus (HBV) vaccine. This review includes lessons learned from vaccination against HBV and the use of an established protective HBV surface antigen antibody level: 10 mIU/mL, an overview of HPV infection-induced and HPV vaccine-induced antibody responses, successful efforts to establish international standardization of serological reagents and associated tools, and 15-year vigilance of HPV vaccine-induced antibody levels in a vaccination cohort against breakthrough infections. This report identifies progress but also gaps on the journey toward the definition of a HPV vaccine-induced correlate of protection.

Keyword(s): antibody ; cancer ; hepatitis B virus ; human papillomavirus ; vaccine

Note: Division of Infections and Cancer,Deutsches Krebsforschungszentrum, / 2025 May 15;156(10):1848-1857 / AG Martin Müller

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Contributing Institute(s):

1. Tumorvirus-spez. Vakzinierungsstrategie (D335)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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