%0 Journal Article
%A Gast, Lena V
%A Gerhalter, Teresa
%A Türk, Matthias
%A Sapli, Alper
%A Mathy, Claudius S
%A Heiss, Rafael
%A Baudin, Pierre-Yves
%A Marty, Benjamin
%A Uder, Michael
%A Nagel, Armin
%T Determination of Tissue Potassium and Sodium Concentrations in Dystrophic Skeletal Muscle Tissue Using Combined Potassium (39K) and Sodium (23Na) MRI at 7 T.
%J NMR in biomedicine
%V 38
%N 4
%@ 0952-3480
%C New York, NY
%I Wiley
%M DKFZ-2025-00384
%P e70009
%D 2025
%Z #LA:E020#
%X Combined 23Na/39K MRI at 7 T can highlight ion disturbances in skeletal muscle tissue. In this work, we investigated if the apparent tissue potassium concentration (aTPC) can be determined in fatty replaced muscles of patients with facio-scapulo-humeral muscular dystrophy (FSHD) and if it can provide additional information to the fat replacement and the apparent tissue sodium concentration (aTSC). The lower leg of 14 patients (six females, eight males; mean age 47.7 ± 14.0 years) with genetically confirmed FSHD and 11 healthy controls (four females, seven males; mean age 47.0 ± 14.0 years) was examined at a 7-T MR system using a dual-tuned 23Na/39K birdcage RF coil. In addition, qualitative and quantitative 1H MR measurements were performed at 7 T to assess the fat replacement and water accumulation. The aTPC and aTSC were determined in seven different muscle regions based on five external references phantoms and corrected for partial volume effects, relaxation biases, and reduced ion concentrations in fat. Results are expressed as median (interquartile range). The measured aTPC was strongly reduced in fat-replaced muscles and was close to zero in totally fat replaced muscles (aTPC = 4.3 mM [2.7 mM] for FF > 80
%K Humans
%K Male
%K Female
%K Magnetic Resonance Imaging
%K Sodium: metabolism
%K Muscle, Skeletal: diagnostic imaging
%K Muscle, Skeletal: metabolism
%K Middle Aged
%K Potassium
%K Adult
%K Phantoms, Imaging
%K Sodium Isotopes
%K 7 T (Other)
%K facio‐scapulo‐humeral muscular dystrophy (Other)
%K potassium MRI (Other)
%K skeletal muscle (Other)
%K sodium MRI (Other)
%K ultrahigh field strength (Other)
%K Sodium (NLM Chemicals)
%K Potassium (NLM Chemicals)
%K Sodium Isotopes (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39962713
%R 10.1002/nbm.70009
%U https://inrepo02.dkfz.de/record/298950